Adrenocorticotropic Hormone (ACTH) Test
The ACTH stimulation test determines the concentration of adrenocorticotropic hormone (ACTH) in the blood. ACTH is a hormone that is produced by the pituitary gland, which is located near the base of the brain. ACTH regulates the synthesis of another hormone known as cortisol. The adrenal glands are two tiny glands positioned above the kidneys, producing cortisol. Cortisol is essential in:
- Combat illness by responding to stress.
- Control blood sugar levels.
- Maintain normal blood pressure.
- Control your metabolism, which is how your body consumes food and energy.
If Cortisol levels are too high or too low might lead to major health concerns.
What are the Uses of ACTH stimulation tests?
An ACTH stimulation test is frequently used in conjunction with a cortisol test to identify pituitary or adrenal gland problems, such as:
- Cushing's syndrome
- Cushing's disease
- Addison's disease
- Hypopituitarism
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Get A Second OpinionWhat Is The Need For An Acth Test?
An ACTH stimulation test may be required if you experience symptoms of more or less cortisol.
Cortisol overdose symptoms include:
- Increase in weight
- The buildup of fat in the shoulder area
- Pink stretch marks on the abdomen, thighs, and/or breasts
- Skin bruises
- Increased body hair
- Muscle weakness
- Fatigue
- Acne
- Weight loss
- Nausea and vomiting
- Diarrhea
- Abdominal pain
- Dizziness
- Darkening of the skin
- Salt craving
- Fatigue
You may also require this test if you have hypopituitarism symptoms. The following symptoms may occur depending on the severity of the disease:
- Loss of appetite
- Irregular menstrual periods
- Infertility in women
- Sensitivity to cold
- Lower sex drive in men and women
- Urinating more often than usual
- Loss of body and facial hair in men
- Fatigue
What Happens During An Acth Blood Test?
The ACTH stimulation test is a specific test used to assess how well your adrenal glands respond to ACTH. It’s often used to diagnose conditions such as Addison’s disease or adrenal insufficiency.
A tiny needle will be used by a healthcare provider to draw blood from a vein in your arm. Following the insertion of the needle, a little quantity of blood will be collected in a test tube or vial. When the needle goes in or out, you may feel a slight sting. This normally takes five minutes.
ACTH Stimulation Test Procedure
- Preparation: Prior to the test, the doctor will instruct you not to eat for at least 8 hours to prevent food from interfering with the test.
- First Blood Draw: A nurse will collect blood from your vein for baseline cortisol measurement.
- ACTH Injection: Next, you will receive an injection of synthetic ACTH. It is to trigger your adrenal glands to secrete cortisol.
- Blood Draw at Follow-Up: 30 min or 60 min post injection, a second blood sample is drawn to measure your cortisol levels again.
- Results: Your doctor can evaluate the function of your adrenal glands based on the change in cortisol levels.
What Is the ACTH Test Price?
ACTH tests also differ in price based on location, country or region, and insurance coverage. On average:
- In India, for example, the cost of the test could be Rs1500 to Rs1800.
- If you have insurance, it may be less, generally falling under lab work or diagnostic services. Always confirm prices with your health care provider or laboratory
How To Prepare For The Acth Test?
Before testing, you may need to fast (not eat or drink) overnight. Since cortisol levels fluctuate throughout the day, tests are normally performed early in the morning.
Risk of ACTH Blood Test?
Having a blood test poses no risk or danger. You may experience some discomfort or bruising where the needle was inserted, but mostly it goes soon.
- Minor Bruising or Bleeding
- Discomfort or Pain
- Infection (Rare)
- Lightheadedness or Dizziness
- Hematoma
- Allergic Reaction (Extremely Rare)
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Book an AppointmentWhat do the findings imply?
An ACTH stimulation test results are frequently compared to cortisol test results and may reveal one of the following:
- Elevated ACTH and cortisol levels may indicate Cushing's illness.
- Low ACTH and high cortisol levels may indicate Cushing's disease or an adrenal gland tumor.
- High ACTH and low cortisol levels may indicate Addison's disease.
- ACTH and cortisol levels are low may indicate hypopituitarism.
Consult your doctor if you have any doubts or confusion on your results.
ACTH Blood Test Normal Range
The normal range for an ACTH blood test may vary slightly among different laboratories, but the following values are a generally accepted guideline:
- ACTH levels: 10 to 60 pg/mL (picogram per milliliter)
This value can vary based upon the time of day, since ACTH is at its peak in the early morning and lowest in the evening.
Important information to know about ACTH testing?
To detect Addison's disease and hypopituitarism, an ACTH stimulation test is occasionally used instead of an ACTH stimulation test. An ACTH stimulation test is a simple blood test that compares cortisol levels before and after an ACTH injection.
