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CCP Antibody Test

The CCP antibody test examines CCP (cyclic citrullinated peptide) antibodies in the blood. CCP antibodies, commonly known as anti-CCP antibodies, are a type of antibody known as autoantibodies. Antibodies and autoantibodies are proteins that the immune system generates. Antibodies protect you from disease by attacking substances such as viruses and bacteria. Autoantibodies can cause disease by mistakenly targeting healthy cells in the body.

CCP antibodies affect healthy tissues in the joints. CCP antibodies in the blood indicate rheumatoid arthritis, which causes joint pain, swelling, and stiffness. CCP antibodies are present in more than 75% of persons with rheumatoid arthritis, and they are almost never found in people who do not have the condition.

Other names: Anti Citrullinated peptide antibody, cyclic citrullinated peptide antibody, citrulline antibody, anti-CCP antibody, anti-cyclic citrullinated peptide, ACPA.

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What is it used for?

A CCP antibody test is used to assist in the diagnosis of rheumatoid arthritis. It is frequently performed simultaneously with or after a rheumatoid factor (RF) test. Another type of autoantibody is the rheumatoid factor. RF testing was once the main means of diagnosing rheumatoid arthritis. However, RF factors have been detected in individuals with various autoimmune disorders and in some healthy people. Several studies have demonstrated that CCP antibodies, compared to RF testing, provide a more accurate diagnosis of rheumatoid arthritis.

What is the purpose of a CCP antibody test?

If you have rheumatoid arthritis symptoms, you may require this test. These include:

  • Joint stiffness
  • Fatigue
  • Low-grade fever
  • Joint pain
  • Joint swelling

This test may also be required if other tests cannot confirm or rule out a diagnosis of rheumatoid arthritis.

What happens during a CCP antibody test?

A small needle will be used by a healthcare expert to draw blood from a vein in the arm. After the insertion of the needle, a little amount of blood will be collected in a test tube or vial. When the needle goes in or out, individuals may feel a minor sting, which usually last less than two minutes.

How to prepare for the test?

Inform the doctor about any medications,vitamins, or dietary supplements you are taking. Some substances may require you to abstain for 8 hours before the test.

Are there any risks to the test?

Having a blood test poses quite little danger. Individuals may feel pain or bruises where the needle was inserted, but most symptoms will go away quickly.

What do the results mean?

If the CCP antibody test results were positive, these antibodies were detected in the blood. A negative result indicates that no CCP antibodies were identified. The importance of these results may be determined by the outcomes of a rheumatoid factor (RF) test and a physical exam. If you have rheumatoid arthritis symptoms and your results show:

  • If you have positive CCP antibodies and positive RF, people most likely have rheumatoid arthritis.
  • Positive CCP antibodies and negative RF may indicate that you have rheumatoid arthritis or will acquire it in the future.
  • If you have negative CCP antibodies and negative RF, you are less likely to have rheumatoid arthritis. The provider may require further testing to determine what is causing the symptoms.

Additional information to know about a CCP antibody test

Rheumatoid arthritis is often difficult to diagnose, especially in its early stages. In addition to the CCP antibody and RF tests, the provider may prescribe one or more additional tests. They include joint x-rays and blood tests that can show signs of inflammation.


**Note- CCP Antibody Test costs in India at different locations may vary

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Frequently Asked Questions

1. Can I have the CCP antibody test if I am pregnant?

Yes, the CCP antibody test can be performed on pregnant women. However, women who are pregnant should discuss the potential risks and benefits of the test with their healthcare provider.

2. How quickly can you get the results of a CCP antibody test?

The results of the CCP antibody test typically take a few days to a week to become available.

3. What conditions can be detected using the CCP antibody test?

The CCP Antibody Test is primarily used to diagnose rheumatoid arthritis, although it may also be used to evaluate other autoimmune diseases such as lupus and Sjogren's syndrome.

4. Is the CCP antibody test painful?

The CCP antibody test involves a simple blood draw and is typically not painful. Some patients may experience mild discomfort at the site where the blood was drawn.

5. Can I eat or drink before the CCP antibody test?

Yes, patients can eat and drink before the CCP antibody test. However, it is recommended that patients avoid fatty or greasy foods before the test, as these can interfere with the accuracy of the results.

6. How often should the CCP antibody test be repeated?

The frequency of CCP antibody test repeats will depend on a patient's individual situation and medical history. Patients should consult their healthcare provider for guidance on how often the test should be repeated.

7. What is the cost of a CCP antibody test?

The cost of a CCP antibody test is approximately Rs. 1200/-

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