What is a Globulin Blood Test?

Globulins are proteins found in the blood. The immune system creates them in the liver. Globulins are crucial for liver function, blood clotting, and infection resistance.

  • Total protein test: This test determines globulin and albumin protein in the blood. Low protein levels may indicate liver or kidney disease.
  • Serum protein electrophoresis: This blood test determines the concentration of each type of protein in the blood, including Gamma globulins. The levels of specific globulins indicate how well the immune system works. As a result, this test can be used to diagnose multiple myeloma and various other conditions.

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What is the globulin test used for?


Why do I need a globulin test?

  • As part of the routine examination
  • To keep track of any liver or kidney issues.
  • When you experience specific symptoms that are globulin test related.

A comprehensive metabolic panel, which is often a component of a standard examination, may include a total protein test. If you exhibit kidney or liver disease signs, the doctor might recommend the test.

A total protein test may be performed together with other tests to evaluate how well the liver is functioning if the doctor suspects a liver problem. They are known as liver function tests. The doctor may prescribe these tests if you have any of the following symptoms or are at risk for liver disease:

A serum protein electrophoresis test determines the concentrations of several globulin subtypes and other proteins in the blood. This test may be prescribed by the doctor to identify problems with the immune system, such as:


What happens during a globulin test?

  • Globulin testing is similar to blood tests. A blood test involves a healthcare provider taking blood from a vein in the arm with a small needle. After the insertion of the needle, a small amount of blood will be collected in a test tube or vial. One may feel a slight sting when the needle goes in or out. This normally takes under five minutes.

How to prepare for the globulin test?

  • No extra preparation is necessary for a globulin blood test.
  • In case additional tests are needed, fasting for a few hours might be necessary.

Are there any risks involved in the test?

A blood test poses no risk. Some people may experience pain or bruises where the needle was inserted, but most of these symptoms will go away shortly.


What do the results mean?

Low globulin levels may indicate liver or renal illness, as well as malnutrition. High globulin levels may indicate:

  • Inflammatory disease
  • Infection
  • Immune disorders
  • Certain cancers, such as malignant lymphoma, multiple myeloma, or Hodgkin lymphoma

Certain medications, dehydration, or other conditions can also cause abnormal readings.

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Frequently Asked Questions

The normal value of globulin levels: Serum globulin: 20-35 grams per liter (g/L) or 2.0 to 3.5 grams per deciliter (g/dL).

If globulin levels fall below the normal range, it can indicate several serious health problems such as renal disease, hepatic dysfunction, celiac disease, inflammatory bowel disease (IBD), and acute hemolytic anemia.

Protein levels in the blood are measured by globulin blood tests. High levels could indicate an autoimmune condition, infection, or malignancy. A low globulin level could indicate liver or kidney illness.

Eating lean protein, such as fish, can help raise total protein levels and treat low globulin. It may also be beneficial to boost the consumption of foods that aid liver and kidney detoxification.

Serum electrophoresis is the name given to the globulin test. It is a blood test that determines the concentrations of four different types of globulins.

Gamma-globulin levels declined after the first stress exposure but they increased after subsequent exposures.

Diabetes risk has also been linked to elevated globulin levels.

Yes, dehydration can have an impact on globulin levels. When people are dehydrated, their globulin levels rise.

Yes, globulin levels are higher in pregnant women. Total protein levels rise during pregnancy and then return to normal after childbirth. This variation is normal and usually not cause for concern.

The cost of the globulin test is approximately Rs. 160- Rs. 300.

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