Degenerative Myopia: Causes and Treatments

Degenerative myopia, also known as pathological or malignant myopia, is a severe form of myopia that progresses rapidly and can lead to significant vision impairment. This condition goes beyond standard nearsightedness and can cause substantial structural changes in the eye. Here, we will delve into the causes, symptoms, types, diagnosis, and treatments for degenerative myopia, providing a comprehensive understanding of this challenging condition.


What is Degenerative Myopia?

Degenerative myopia is characterized by the elongation of the eyeball, which causes light rays to focus in front of the retina rather than directly on it. This elongation not only leads to severe nearsightedness but also results in degenerative changes in the retina and choroid, such as thinning and atrophy.

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Causes of Degenerative Myopia

Genetic Factors

Genetics play a pivotal role in the development of degenerative myopia. If one or both parents have this condition, the likelihood of their children developing it increases significantly. Specific genes have been identified that are associated with the risk of developing high myopia and its degenerative form.

Environmental Influences

While genetics are a primary factor, environmental influences cannot be ignored. Factors such as excessive near work, lack of outdoor activities, and prolonged screen time have been linked to the progression of myopia, potentially exacerbating the condition into its degenerative form.

Structural Abnormalities

Degenerative myopia often involves structural abnormalities in the eye, such as a thinner sclera or weaker connective tissues. These abnormalities contribute to the progressive elongation of the eyeball and the accompanying retinal changes.


Symptoms of Degenerative Myopia

Progressive Vision Loss

One of the most notable symptoms of degenerative myopia is the gradual worsening of distance vision. This progression can be swift and severe, leading to significant visual impairment.

Floaters and Flashes

Patients with degenerative myopia often report seeing floaters (small, shadowy shapes that drift across the visual field) and flashes of light. These symptoms are indicative of changes in the vitreous humor and potential retinal complications.

Retinal Detachment

As the retina stretches and thins, the risk of retinal detachment increases. Symptoms include sudden flashes of light, a shadow or curtain over part of the visual field, and a sudden increase in floaters. Retinal detachment is a medical emergency requiring immediate attention.


Types of Degenerative Myopia

Primary Degenerative Myopia

Primary degenerative myopia is typically inherited and manifests early in life. It progresses rapidly and is often associated with significant retinal changes and complications.

Secondary Degenerative Myopia

Secondary degenerative myopia results from other ocular or systemic conditions. These may include conditions such as Marfan syndrome, Ehlers-Danlos syndrome, or other connective tissue disorders. Management of the underlying condition is crucial in addressing secondary degenerative myopia.


Diagnosis of Degenerative Myopia

Comprehensive Eye Examination

A thorough eye examination is essential for diagnosing degenerative myopia. This includes a refraction test to measure the degree of myopia, as well as a dilated eye exam to examine the retina and other structures within the eye.

Optical Coherence Tomography (OCT)

OCT is an advanced imaging technique that provides detailed cross-sectional images of the retina. This helps in assessing the extent of retinal thinning, choroidal atrophy, and other structural changes associated with degenerative myopia.

Fundus Photography

Fundus photography involves taking detailed photographs of the retina. These images are crucial for documenting the progression of degenerative changes and identifying complications such as retinal detachment or macular degeneration.

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Treatment Options for Degenerative Myopia

Pharmacological Interventions

Pharmacological treatments aim to slow the progression of myopia and manage associated complications. These may include:

  • Atropine Eye Drops: Low-dose atropine drops have been shown to slow the progression of myopia in children, potentially reducing the risk of developing degenerative myopia.
  • Anti-VEGF Injections: For patients with myopic macular degeneration, anti-VEGF injections can help manage neovascularization and prevent further vision loss.

Optical Treatments

Optical treatments focus on correcting refractive errors and improving visual acuity. These include:

  • Contact Lenses: Specialized contact lenses, such as orthokeratology (Ortho-K) lenses, are designed to reshape the cornea and reduce the degree of myopia.
  • Spectacles: High-index lenses can effectively correct severe myopia, though they may be thicker and heavier than standard lenses.

Surgical Interventions

In advanced cases of degenerative myopia, surgical interventions may be necessary to address complications and improve vision:

  • Laser-Assisted in Situ Keratomileusis (LASIK): LASIK surgery reshapes the cornea to correct refractive errors. However, it may not be suitable for individuals with significant retinal changes or very high myopia.
  • Phakic Intraocular Lenses (IOLs): Phakic IOLs are implanted in the eye to correct severe myopia. This option is considered for patients who are not candidates for LASIK.
  • Vitrectomy: In cases of retinal detachment or significant vitreous changes, a vitrectomy may be performed to remove the vitreous gel and repair the retina.

Preventive Measures for Degenerative Myopia

Regular Eye Check-Ups

Early detection and monitoring are critical for managing degenerative myopia. Regular eye check-ups can help identify changes in vision and address complications promptly.

Lifestyle Modifications

Adopting healthy lifestyle habits can help slow the progression of myopia:

  • Limit Screen Time: Reducing the amount of time spent on digital devices can alleviate eye strain and prevent the worsening of myopia.
  • Encourage Outdoor Activities: Spending time outdoors has been shown to reduce the risk of myopia progression in children and adolescents.

Parental Awareness and Education

Educating parents about the risks and signs of degenerative myopia can lead to early intervention and better management of the condition.

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Frequently Asked Questions

1. What are the symptoms of degenerative myopia?

Symptoms include blurred vision, floaters, and retinal detachment.

2. What causes degenerative myopia?

It is caused by the elongation of the eyeball, often hereditary.

3. How is degenerative myopia diagnosed?

Diagnosis is through eye exams, including measuring the axial length of the eye.

4. What treatments are available for degenerative myopia?

Treatments include corrective lenses, medications to slow progression, and surgery for complications like retinal detachment.

5. Can degenerative myopia be prevented?

While not preventable, progression can be slowed with early intervention.

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