Amikacin is an antibiotic used for many types of bacterial infections. These include joint infections, intra-abdominal infections, meningitis, pneumonia, sepsis, and urinary tract infections. It is also used in the treatment of multidrug-resistant tuberculosis.
This medicine is used to prevent or treat a wide range of bacterial infections. Amikacin is a class of drugs known as aminoglycoside antibiotics. It works by stopping the growth of bacteria.
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Get A Second OpinionDrug interactions might change the way your drugs work or increase the risks of serious side effects. Keep a list of all the products you use and share them with your doctor and pharmacist. Do not suddenly start, stop or change the dosage of any medicine without your doctor's approval.
Other drugs that may affect the kidneys or the hearing may increase the risk of kidney damage or hearing loss if taken with amikacin.
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Book an AppointmentIf you forget to take any dose, take it at the time remember but never take two doses at once.
Do not take extra doses of this medicine. It might cause you something serious, immediately contact a doctor.
Please refer to the product instructions and your pharmacist for storage details. Keep all drugs away from pets and children. Do not flush the medication down the toilet or pour it into the sink unless instructed to do so. Discard this product properly when it has expired or is no longer needed. Consult your pharmacist about the local waste disposal company.
| Amikacin | Gentamicin |
|---|---|
| Amikacin is an antibiotic medication | Gentamicin is an antibiotic medication |
| Molecular Formula: C22H43N5O13 | Formula: C21H43N5O7 |
| Molar mass: 586 g/mol | Molecular Formula: C21H43N5O7 |
| This medicine is used to prevent or treat a wide range of bacterial infections. | Gentamicin used to treat several types of bacterial infections |
| Amikacin injection is from the class of medications called aminoglycoside antibiotics. | Drug Class: Aminoglycoside antibiotic |
Amikacin exhibits strong activity against specific Gram-positive bacteria like Staphylococcus and Nocardia. It is also effective against non-tuberculous mycobacterial infections and, in cases where first-line treatments are ineffective, sensitive strains of tuberculosis.
Amikacin is administered once daily to outpatients and may be considered for mild to moderate urinary tract infections caused by ESBL-producing E. coli. This option is particularly viable in cases where patients cannot tolerate carbapenems or in settings with limited medical resources, provided close monitoring of renal function is maintained.
Amikacin injections are utilized to treat severe bacterial infections such as meningitis, bloodstream infections, abdominal infections, bone infections, pneumonia, joint infections, skin infections, and urinary tract infections caused by susceptible bacteria.
Amikacin sulfate injection is given intravenously or intramuscularly. Amikacin should not be physically premixed with any other medicinal drugs but should be administered separately based on the recommended dose and route. The patient's initial body weight should be obtained to ensure accurate dosage calculation.
Amikacin is a highly effective amino-glycoside, highly effective against extended-spectrum beta-lactamase (ESBL) bacteria. Older patients suffer from more urinary tract infections (UTIs) and have a higher frequency of infections with resistant bacteria, especially among frail nursing home residents.
Once-daily amikacin was shown to kill more than 8 h higher than all other drugs administered as monotherapy for both strains tested (P < 0.01). Regrowth by 24 h was greatest for the amikacin regimen (P < 0.01) but was evident for all monotherapy regimens against both strains.
The plasma elimination half-life of amikacin in adults with normal renal function is usually 2-3 hours. 94-98 percent of a single IM or IV amikacin dose is excreted unchanged by glomerular filtration within 24 hours.
To reduce the risk of aminoglycoside toxicity, it's important to tailor the loading and maintenance doses of the medication according to the estimated creatinine clearance. Monitoring the serum levels of aminoglycosides is crucial, along with addressing any volume depletion and correcting electrolyte imbalances, particularly potassium and magnesium.
Amikacin induced nephrotoxicity primarily through oxidative reactions. This antibiotic, widely used to combat bacterial infections, can lead to significant kidney damage in both clinical settings and experimental studies.
The typical treatment duration for Amikacin ranges from 7 to 10 days. Whenever feasible, treatment should be kept short-term. The total daily dose across all administration routes should not exceed 15 mg/kg/day.
Disclaimer: The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.
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