Cabergoline: A Complete Guide

Cabergoline is used to treat various medical conditions caused by elevated levels of the hormone prolactin. It can address:

  • Menstrual issues
  • Male and female fertility problems
  • Pituitary prolactinoma (tumors of the pituitary gland)

How it works:

  • Prevents the pituitary gland from producing and releasing prolactin.
  • Treatment usually stops when prolactin levels are normal for 6 months.
  • May be prescribed again if symptoms reappear.
  • Available in tablet form for oral dosage.

Cabergoline Tablet Uses

  • Treats elevated prolactin levels: Helps manage symptoms like unwanted breast milk, missed periods, and fertility issues in women, and enlarged breasts and reduced sexual desire in men.
  • Ergot drug: Blocks the release of prolactin from the pituitary gland.
  • Parkinson's disease: Sometimes used to treat movement, muscle control, and balance issues.

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How to Use

  • Dosage: Take orally, with or without food, typically twice a week as prescribed by your doctor.
  • Adjustments: Dose depends on your medical condition and treatment response.
  • Regular intake: Take the medication consistently, and mark your calendar to help remember the doses.

Cabergoline Side Effects

Common Side Effects:

Serious Side Effects:

  • Shortness of breath
  • Difficulty breathing when lying down
  • Cough
  • Chest pain
  • Swelling of hands, feet or ankles
  • Decrease in urination
  • Pain in back, side, or groin
  • Lumps or pain in the stomach area
  • Abnormal vision

Precautions To Be Taken For Cabergoline

  • Allergies: Inform your doctor if you're allergic to cabergoline or other ergot medications.
  • Medical history: Discuss any history of kidney problems, liver problems, bipolar disorder, or Parkinson's disease with your doctor.
  • Heart valve disease: Your doctor may assess your heart valves and conduct tests if necessary.
  • Liver conditions: Inform your doctor if you have any liver-related health issues.
  • Pregnancy and breastfeeding: Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Cabergoline can affect breast-milk production.
  • Dizziness: Cabergoline can cause dizziness, especially when getting up too quickly. Rise slowly to avoid this issue.

Dosage Guidelines

  • Interfering drugs: Some medications, like antipsychotics, lorcaserin, metoclopramide, and certain antifungal agents, can affect how cabergoline works.
  • Consult your doctor: Always discuss potential drug interactions with your healthcare provider.

Overdose

  • Signs: Extreme dizziness, fainting, mental/mood changes (e.g: hallucinations).
  • Action: Contact a poison control center or seek immediate medical attention if overdose is suspected.

Note

  • Do not share: This medication is prescribed specifically for you.
  • Regular monitoring: Laboratory tests (e.g., prolactin levels, EKG) may be conducted to monitor your progress and check for side effects.

Missed Dose

  • If missed: Take as soon as you remember, unless it's close to the next dose. Do not double up on doses.

Storage

  • Conditions: Store at room temperature away from light, heat, and moisture. Do not store it in the bathroom.
  • Disposal: Properly discard when expired or no longer needed. Consult your pharmacist for disposal guidance.

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Cabergoline vs Bromocriptine

Cabergoline Bromocriptine
Formula: C26H37N5O2 Formula: C32H40BrN5O5
Molecular Weight: 451.6 g/mol Molar mass: 654.595 g/mol
Elimination half-life: 63–69 hours (estimated) Elimination half-life: 12-14 hours
Cabergoline is an ergot derivative Bromocriptine is an ergoline derivative
Cabergoline is used to treat various forms of medical conditions caused by the development of too much of the hormone prolactin. Used in the treatment of pituitary tumors, neuroleptic malignant syndrome, Parkinson's disease, hyperprolactinemia, and, as an adjunct, type 2 diabetes.

Citations

Cabergoline
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Frequently Asked Questions

1. What is the drug Cabergoline used for?

For the treatment of hyperprolactinemia, cabergoline is used (high levels of prolactin, a natural substance that helps to breastfeed women produce milk but can cause symptoms such as infertility, sexual issues, and bone loss density in women who are not breast-feeding or can happen bone loss in men).

2. What is the benefit of taking Cabergoline?

The advantage of taking cabergoline is that the amount of prolactin in your blood can be decreased and the effects you have encountered can be reduced. It works by raising a chemical called dopamine in the brain, which decreases the amount of prolactin released.

3. How quickly does Cabergoline work?

The impact is prompt and persistent (within 3 hours of administration) and (up to 7-28 days in healthy volunteers and hyperprolactinemic patients, and up to 14-21 days in puerperal women). The dose-dependent prolactin-lowering effect is related to both the degree of effect and the duration of action.

4. Does Cabergoline work immediately?

Absorption: Mean plasma peak levels of 30 to 70 picograms (pg)/mL of Cabergoline were observed within 2 to 3 hours following single oral doses of 0.5 mg to 1.5 mg administered to 12 healthy adult volunteers.

5. What happens when you stop taking Cabergoline?

If you don't take it as recommended, it comes with significant risks. If you unexpectedly stop taking the medication or don't take it at all, the blood levels of prolactin will remain high. High prolactin levels in women can alter ovulation, menstrual cycles, and the development of breast milk.

6. Is Cabergoline an antidepressant?

Cabergoline, an agonist of the dopamine receptor, has an antidepressant-like property and increases signalling of the brain-derived neurotrophic factor. Psychopharmaceuticals (Berl).

7. Is Cabergoline a hormone drug?

Cabergoline is used to treat an excess of hormones when too much prolactin is found in the blood (also called hyperprolactinemia). For purposes not specified in this drug guide, Cabergoline can also be included.

8. Does Cabergoline treat PCOS?

Some research indicates that cabergoline administration can normalize androgen levels and boost menstrual irregularity in PCOS women. They conclude that cabergoline may play a useful role in treating menstrual abnormalities in PCOS patients by reducing prolactin secretion (30-31).


Disclaimer: The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.

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