Cefepime: Know Its Uses, Side Effects and Precautions

Cefepime, a fourth-generation cephalosporin antibiotic, is highly effective against a wide range of bacterial infections. It acts by inhibiting bacterial growth, making it a crucial treatment option in medical settings.

What is Cefepime Used For?

Cefepime is prescribed to combat infections caused by both Gram-positive and Gram-negative bacteria. It is administered via injection into muscles or veins under medical supervision.

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How to Use Cefepime

Follow your doctor's instructions carefully. Cefepime is typically administered via injection into a muscle or vein. Ensure thorough understanding of preparation and usage instructions.

Key Instructions for Use:

Thaw frozen pre-mixed solutions properly before use.
Check for particles or discoloration before administration.
Shake thawed solutions vigorously and check for leaks.
Use at regular intervals to maintain effectiveness.

Side Effects of Cefepime

Headache
Diarrhea
Pain, redness or swelling at injection site
Gastrointestinal issues like stomach cramps, nausea or vomiting
Skin reactions such as rash or itching
Respiratory symptoms like difficulty breathing or swallowing

Precautions While Taking Cefepime

Inform your doctor about allergies to antibiotics or any other medications.
Cefepime may affect the efficacy of live bacterial vaccines, consult your doctor before vaccinations.
Pregnant or breastfeeding women should discuss risks with their healthcare provider.
Be aware of potential drug interactions and inform all healthcare providers of medications you are taking.

Dosage Instructions

Take missed doses as soon as possible; do not double up if it's almost time for the next dose.
In case of overdose symptoms (such as difficulty breathing), seek immediate medical assistance.

Storage Guidelines

Store Cefepime away from heat, light, and moisture to maintain its potency.
Keep out of reach of children.

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Cefepime vs Ceftriaxone

Cefepime	Ceftriaxone
Cefepime is a cephalosporin antibiotic of the fourth generation.Cefepime has a broad spectrum of activity against Gram-positive and Gram-negative bacteria	Ceftriaxone, also known as Rocephin, is an antibiotic that is used to treat a variety of bacterial infections.
Cefepime is an antibiotic that is used to treat a wide range of bacterial infections. This medication is a cephalosporin antibiotic, which is a type of antibiotic.	Used to treat bacterial infections that are serious or life-threatening, such as E. coli, pneumonia, or meningitis. Ceftriaxone is also used to prevent infection in patients undergoing specific types of surgery.
It works by preventing bacterial growth.	It works by interfering with the cell wall formation of bacteria. Ceftriaxone weakens the bonds that hold the bacterial cell wall together, allowing holes to form. This kills the bacteria that are causing the infection.

Citations

Efficacy and safety of cefepime: a systematic review and meta-analysis, ID:10.1016/S1473-3099(07)70109-3

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Frequently Asked Questions

1. What is Cefepime used to treat?

Cefepime injection is used to treat bacterial infections such as pneumonia, skin, urinary tract, and kidney infections. Cefepime injection is used to treat abdominal (stomach area) infections in conjunction with metronidazole (Flagyl).

2. What is another name for Cefepime?

Cephalosporin antibiotics Rocephin (ceftriaxone sodium) and Maxipime (cefepime hydrochloride) are used to treat a variety of bacterial infections, including severe or life-threatening infections.

3. Can cefepime be given orally?

Cefepime does not work when taken orally (as a tablet or capsule).

4. Is cefepime a strong antibiotic?

Cefepime is a cephalosporin antibiotic. It works by combating bacteria in the body. Cefepime injection is used to treat a wide range of bacterial infections, including those that are severe or life-threatening.

5. What bacteria does cefepime treat?

Cefepime is a broad-spectrum cephalosporin antibiotic that has been used to treat bacteria that cause pneumonia, skin infections, and urinary tract infections. Pseudomonas, Escherichia, and Streptococcus species are among these bacteria.

6. Is Cefepime used to treat sepsis?

The majority of broad-spectrum antibiotics used to treat sepsis are active against Gram-positive organisms.

7. How long does it take for cefepime to work?

It is extremely soluble in water. MAXIPIME for Injection is available in 500 mg, 1 g, and 2 g cefepime strengths for intramuscular or intravenous administration.

8. Can cefepime cause confusion?

These patients experienced prolonged confusion with temporospatial disorientation and hallucinations for 2–8 days after cefepime. A quarter of the cases also had bilateral distal myoclonus.

9. Is cefepime safe in renal failure?

Cases of cefepime neurotoxicity in patients with renal failure have been reported infrequently. Cefepime's neurotoxicity may be underestimated, and the frequency of its neurotoxic effects may be underappreciated.

Disclaimer: The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.