What is Cefoperazone?

Cefoperazone is a semisynthetic broad-spectrum cephalosporin effective against pseudomonas infections. Cephalosporins are third-generation antibiotic agents that treat various bacterial infections caused by susceptible organisms in the body.

The bacterial infections include:

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Cefoperazone Uses

Cefoperazone is used for various treatments:

  • Bone disease
  • Escherichia coli infections
  • Genital disease
  • Haemophilus infections
  • Pneumonia
  • Bacterial infections
  • Proteus infections
  • Pseudomonas infection
  • Skin diseases
  • Soft tissues
  • Urinary tract infections

For further use of Cefoperazone tablets, consult your doctor.


Cefoperazone Side Effects

Common Side effects includes:

Serious Side Effects:

  • Hypersensitivity
  • Hematology
  • Hepatic
  • Gastrointestinal
  • Blood and lymphatic system disorders
  • Immune system disorders
  • Hepatobiliary disorders
  • Skin tissue disorders
  • Vascular Disorders

Precautions while taking Cefoperazone

If Cefoperazone is suggested to a patient without a proven bacterial infection, the tablets have very little chance of benefiting the patient. In fact, they will have adverse effects on the body. Patients who are taking this medication should avoid alcohol for 72 hours.

Avoid using Cefoperazone if you have faced these problems:

If you ever get allergic, Inform your doctor if you have these problems:


Cefoperazone Dosage (For Adult Dose)

  • Endometritis: 1 to 2 g IV every 12 hours should be continued for 48 hours until clinical improvement has been seen.
  • Febrile Neutropenia: 1 to 2 g IV every 12 hours. This therapy should be continued for 14 days.
  • Joint infection: 1 to 2 g IV in every 12 hours for 3 to 4 weeks. The longer therapy can be for six weeks.
  • Pelvic inflammatory disease: 1 to 2 g IV every 12 hours for 48 hours until any improvement is observed in the patient's body.
  • Pneumonia: 1 to 2 g IV every 12 hours for 7 to 21 days which depends on the causative organisms.

Overdose of Cefoperazone

Overdose of a drug can be accidental. If you have taken more than the prescribed tablets, there is a chance of getting a harmful effect on your body's functions. Overdose of a medicine can lead to some medical emergency.


Missed Dose

Missing one or two doses of this medications typically has no effect, and skipping doses usually poses no problem. However, timely dosage is crucial for some medications to work effectively, as missing doses may lead to sudden chemical changes in the body. Your doctor may advise taking the missed dose promptly in certain cases.


Cefoperazone Warnings

  • Hypersensitivity reactions
  • Clostridium Difficile-Associated Diarrhea
  • Hemorrhage

People With Serious Health Conditions

  • Pregnant women: The use of this medication during pregnancy hasn't been thoroughly studied, but it doesn't pose a significant risk of pregnancy loss or birth defects. However, it's advisable to consult your doctor before taking the medication to ensure safety.
  • Breastfeeding: This medication passes into breast milk and can cause side effects in children who are breastfed. These can include diarrhea, vomiting, and rash. Before taking it while breastfeeding, consult your doctor.

Storage of Cefoperazone

Store this medication away from heat, air, and light to prevent damage and harmful effects. Keep it in a safe place, out of children's reach, at room temperature (68-F to 77-F or 20-C to 25-C). Before taking this medication, consult your doctor. If you experience any problems or side effects, seek immediate medical attention. Carry your medication while travelling to address emergencies, and always follow your doctor's prescription and advice.

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Cefoperazone vs Ceftriaxone

Cefoperazone Ceftriaxone
It is a semisynthetic broad-spectrum cephalosporin. It’s a cephalosporin antibiotic.
Side effects are vomiting, nausea, haematology, hepatic and gastrointestinal Side effects are sore throats, fever, cough, breathlessness, unusual bleeding and weakness
1 to 2 g IV in every 12 hours to continue until 48 hours till the clinical improvement has been seen. Adult dose for bacteremia IS 1 to 2 g IV or IM once in a day. The duration of therapy should be 4-14 days

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Frequently Asked Questions

1. What is the use of cefoperazone and sulbactam injection?

Cefoperazone is a semisynthetic broad-spectrum cephalosporin. It’s effective against pseudomonas infections. These are third-generation antibiotic agents which work in the treatment of various bacterial infections that are caused by the susceptible organisms in the body.

2. Can cefoperazone cross the blood-brain barrier?

These are not very useful for the treatment of meningitis as this doesn’t penetrate the blood-brain barrier.

3. Is cefoperazone sulbactam safe in pregnancy?

Cefoperazone is not evaluated for pregnant women. If a woman is using the drug during her pregnancy there is no such high risk of pregnancy loss, birth defects or any other problems. But to be on the safe side, consult your doctor before taking the medicine.

4. What generation is cefoperazone?

These are third-generation antibiotic agent which work in the treatment of various bacterial infections that are caused by the susceptible organisms in the body.

5. What is cefoperazone used for?

Cefoperazone is a broad-spectrum antibiotic used to treat bacterial infections such as respiratory tract infections, urinary tract infections, skin infections, and intra-abdominal infections. It works by inhibiting the growth of bacteria and is particularly effective against gram-negative organisms.

6. Can I take Cefoperazone with other medications?

Before taking Cefoperazone, inform your doctor about all medications you are currently taking, including prescription drugs, over-the-counter medications, vitamins, and herbal supplements. Some medications may interact with Cefoperazone, affecting its effectiveness or increasing the risk of side effects.

7. What are the benefits of cefoperazone sulbactam?

Cefoperazone sulbactam is a combination antibiotic that enhances the effectiveness of cefoperazone by inhibiting beta-lactamase enzymes produced by bacteria.

8. What is Inj Magnex Forte?

Inj Magnex Forte is a brand name for the cefoperazone sulbactam injection, commonly used to treat severe bacterial infections.

9. What is Injection Zostum used for?

Injection Zostum is used to treat a wide range of bacterial infections and contains cefoperazone and sulbactam.


Disclaimer: The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.

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