Your Guide to Cisplatin: Uses and Side Effects Explained

Cisplatin is a chemotherapy drug used to treat a number of cancers. These include testicular cancer, ovarian cancer, cervical cancer, breast cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, mesothelioma, brain tumor, and neuroblastoma. It is administered by injection into a vein.

Cisplatin Uses

Cisplatin is a chemotherapy drug used to treat various cancers, including:

Testicular cancer
Ovarian cancer
Cervical cancer
Breast cancer
Bladder cancer
Head and neck cancer
Esophageal cancer
Lung cancer
Mesothelioma
Brain tumor
Neuroblastoma

Cisplatin works by slowing down or stopping the growth of cancer cells. It is administered by injection into a vein.

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How to Use Cisplatin Vial

Based on medical condition, body size and response to treatment.
Increase fluid intake and urinate frequently during treatment to prevent kidney side effects. Intravenous fluids should be administered with this medicine.
If the medicine contacts your skin, wash immediately and thoroughly with soap and water.

Cisplatin Side Effects

Common Side Effects include:

Nausea and vomiting
Diarrhea
Temporary hair loss
Loss of taste
Hiccups
Dry mouth and skin
Dark urine
Decreased sweating
Signs of dehydration
Rash and itching
Blurred vision
Dizziness and drowsiness
Headache

Serious Side Effects include:

Allergic reactions (blisters, redness, peeling skin)
Restlessness and lightheadedness
Stomach, abdominal and body pain
Swelling of legs, face and throat
Numbness
Reduced white blood cells
Bruising and bleeding
Anemia
Loss of appetite
Kidney effects
Changes in hearing

Precautions Taken For Cisplatin

Allergies: Inform your doctor if you're allergic to Cisplatin or similar drugs like carboplatin.
Medical History: Discuss your history of kidney disease, blood disorders, hearing problems, and mineral imbalances.
Vaccinations: Avoid immunizations without doctor’s consent and contact with recently vaccinated individuals.
Infection Prevention: Wash hands thoroughly and avoid activities that risk cuts or bruises.
Fertility and Pregnancy: Cisplatin may affect fertility and harm unborn children. Reliable birth control is recommended during and after treatment.
Breastfeeding: Not recommended as Cisplatin passes into breast milk and may harm the infant.

Note

Medical Tests: Regular kidney/liver function, blood counts, and hearing tests are necessary.
Interactions: Cisplatin can interact with other drugs, including antibiotics, anti-seizure drugs, and diuretics. Consult your doctor before starting or changing medication.

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Overdose

In case of overdose, seek emergency medical attention immediately.

Missed Dose

If you miss a dose, contact your doctor or pharmacist for a new dosing schedule.

Storage

Instructions: Refer to product instructions or consult your pharmacist.
Safety: Keep away from children and pets. Do not flush medications unless instructed. Discard properly when expired or no longer needed.

Cisplatin Vs Carboplatin

Cisplatin	Carboplatin
Cisplatin is the generic name and the trade name is drug Platinol	sold under the trade name Paraplatin
Formula: [Pt(NH3)2Cl2]	Formula: C6H12N2O4Pt
Molar mass: 301.1 g/mol	Molar mass: 371.249 g/mol
A chemotherapy medication	A chemotherapy medication
Cisplatin is used to treat head and neck cancer, testicular cancer, ovarian cancer, cervical cancer, breast cancer, bladder cancer, esophageal cancer, lung cancer, mesothelioma, brain tumor.	Carboplatin used to treat a number of forms of cancer.
Injected into a vein.	Injected into a vein.

Citations

Unexpected therapeutic effects of cisplatin

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Frequently Asked Questions

1. Is cisplatin a strong chemo drug?

Platinum-based chemotherapy drugs are among the most potent and widely used anticancer drugs. They have toxic side effects, however, and tumors can become resistant to them. Cisplatin is the most common platinum chemotherapy drug.

2. What are side effects of Cisplatin?

Reduce in the number of white blood cells
Bruising and bleeding
Anaemia (low number of red blood cells)
Feeling sick
Loss of appetite
Effects the kidneys
Changes in hearing.

3. How does cisplatin kill cancer cells?

Cisplatin is one of the most effective anti-cancer agents widely used in the treatment of solid tumors. It is generally considered to be a cytotoxic drug that kills cancer cells by damaging DNA and inhibiting DNA synthesis.

4. What type of cancer does cisplatin treat?

Cisplatin or cis-diamminedichloroplatinum (II) is a well-known chemotherapy drug. It has been used to treat a number of human cancers including bladder, head and neck, lung, ovarian and testicular cancers.

5. How bad is cisplatin?

Cisplatin may cause severe kidney problems. Tell your doctor right away if you have blood in your urine, changes in your urinary frequency or amount of urine, difficulty breathing, drowsiness, increased thirst, loss of appetite, nausea or vomiting, swelling of your legs or lower legs, or weakness.

6. How long does cisplatin stay in the body?

Chemotherapy remains in the body within 2-3 days of treatment, but there are some short-term and long-term side effects that patients may experience. Not all patients will experience all of these side effects, but many will experience at least a few.

7. How long do the effects of cisplatin last?

Nausea and vomiting usually begin within 1 to 4 hours of treatment and last up to 24 hours. Various levels of vomiting, nausea and/or anorexia may persist for up to 1 week after treatment.

8. Will I lose my hair when taking cisplatin?

Yes, hair loss can happen when taking cisplatin

9. Can cisplatin cause kidney damage?

Cisplatin is a potent and valuable chemotherapy agent used to treat a wide range of malignancies. Renal tubular dysfunction and cumulative impairment of renal function, as evidenced by a decrease in the glomerular filtration rate (GFR), may be dose-limiting.

10. Can cisplatin cause heart problems?

Cisplatin is unique in that it can cause late cardiovascular complications such as hypertension, LV hypertrophy, myocardial ischemia, and MI for up to 10 to 20 years after remission of metastatic testicular cancer.

Disclaimer: The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.