What is Clopidogrel?

Clopidogrel is a prescription medication available as a Plavix brand-name drug and as a generic drug. However, in certain cases, it may not be available as a brand-name drug in all strengths or forms. Clopidogrel is only available as an oral tablet.

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Clopidogrel Uses

  • Clopidogrel is used to prevent blood clots in conditions like chest pain, peripheral artery disease, heart attack, or stroke.
  • It may be part of combination therapy, requiring additional medications like aspirin, as determined by your doctor.

Clopidogrel Side effects

common side effects
  • Tiredness
  • Weakness
  • Itchy skin
  • Pale-looking skin
  • Fever
  • Fast heart rate
  • Shortness of breath
  • Headache
  • Trouble speaking
  • Difficulty understanding language (aphasia)
  • Confusion
  • Low amount of urine
  • Pink urine
  • Stomach pain
  • Nausea
  • Vomiting
  • Diarrhea
  • Vision loss
Serious Side Effects:
  • Unexplained bleeding
  • Blood in urine (pink, red, or brown-colored)
  • Red or black stools
  • Unexplained bruises or bruises that enlarge
  • Coughing up blood
  • Blood clots
  • Vomiting blood
  • Purplish spots (purpura) on the skin
  • Mouth (mucous membrane) bleeding
  • Yellowing of skin (jaundice)
  • Whitening of eyes (jaundice)
  • Bleeding
  • Coma
  • Stroke
  • Seizure

How to use Clopidogrel

  • Read the pharmacist's Medication Guide before starting Clopidogrel and with each refill.
  • Take Clopidogrel orally once daily, with or without food, as directed by your doctor.
  • Take it regularly at the same time each day to maximize its benefits.
  • Your medical condition and response to treatment determine the dosage and duration of treatment.
  • If using Clopidogrel to prevent clots after a stent implant or procedure, take it with aspirin for the prescribed duration.
  • Continue taking Clopidogrel even if you are feeling well; do not stop without consulting your doctor.
  • Avoid grapefruit or grapefruit juice while on Clopidogrel unless advised otherwise by your doctor.
  • Seek immediate medical attention if experiencing signs of a new heart attack or stroke.

Precautions while taking Clopidogrel

  • Before using this medicine, inform your doctor or pharmacist about your medical history, especially regarding bleeding disorders, recent surgery, serious injury/trauma, liver disease, and haemophilia.
  • Take precautions to avoid injury, such as using care with sharp objects and avoiding contact sports.
  • Inform your doctor of all medications before surgery, as you may need to stop taking Clopidogrel for at least five days prior to the procedure.
  • Before taking this medication, notify your doctor or pharmacist of any allergies to Clopidogrel or similar antiplatelet drugs, as well as any other allergies.

How it works

  • Clopidogrel is classified as a platelet inhibitor or P2Y12 ADP platelet receptor inhibitor of the thienopyridine class, which functions similarly to other medications in its class.
  • It is used to prevent platelets from sticking together, thus preventing the formation of blood clots.

Interactions

  • Drug interactions can alter the effectiveness of medications or increase the risk of severe side effects. Always consult your doctor before starting, stopping, or adjusting medication dosage.
  • Tipranavir is a product known to interact with Clopidogrel. If taking aspirin concurrently, consult your doctor to determine whether to continue or discontinue
  • Clopidogrel, especially after a coronary stent procedure or for certain heart conditions.
  • Clopidogrel may affect the elimination of other drugs from the body, potentially impacting their efficacy. Examples include dasabuvir and repaglinide.
  • Exercise caution when using other medications, as Clopidogrel may interact with pain relievers/fever reducers like NSAIDs (ibuprofen, naproxen, aspirin), increasing the risk of bleeding/antiplatelet effects. Consult your pharmacist for safe usage.

Clopidogrel Vs Aspirin

Clopidogre Aspirin
Clopidogrel is an antiplatelet medication Aspirin is also known as acetylsalicylic acid
Brand name Plavix It is sold under the brand names Ecosprin, Sprin, Aspro, Eprin, and Delisprin.
Formula - C16H16ClNO2S·HCl Formula: C₉H₈O₄
Clopidogrel is used for preventing blood clots when you have chest pain, peripheral artery disease, poor circulation in your legs, heart attack, or stroke. It is a medication used for reducing pain, fever, or inflammation.

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Frequently Asked Questions

Clopidogrel is used for preventing blood clots when you have chest pain, peripheral artery disease (poor circulation in your legs), heart attack, or stroke. As part of combination therapy, this drug can be used. That means you may need to take other medications with it. Your doctor will determine if this medication should be used with other medications, such as aspirin.

The common side effects are-

  • Weakness
  • Bleeding
  • Itchy skin
  • Pale-looking skin
  • Fever
  • Fast heart rate
  • Shortness of breath
  • Headache
  • Trouble speaking

Clopidogrel comes as a tablet to be taken by mouth. It's usually taken once a day with or without food. Take clopidogrel at about the same time every day. Follow all the directions given on your prescription label carefully and ask your doctor or pharmacist to explain any part you don't understand.

Aspirin and Plavix which is also known as clopidogrel bisulfate are drugs used to prevent blood clots. Aspirin and Plavix belong to different classes of drugs. Plavix is an anticoagulant and aspirin is a non-steroidal anti-inflammatory drug (NSAID). Aspirin is also used to reduce fever and to treat pain and inflammation in the body.

You're not likely to have blood pressure changes while you're taking Plavix. However, sudden drops in blood pressure may be a symptom of severe internal bleeding, which is a possible side effect of Plavix.

You may notice that you bruise or bleed more easily and that it will take longer to stop bleeding while you are taking clopidogrel. This shows that Clopidogrel is still working. However, if bleeding is excessive, prolonged, or if you notice blood in your urine or stool, seek emergency medical advice.

Arthralgia and back pain are also known to occur when used. There have been case reports linking arthritis to the use of clopidogrel.

Arthralgia and back pain are also known to occur when used. There have been case reports linking arthritis to the use of clopidogrel. We describe the case of a 64-year-old man who reported symptoms of fever and joint pain following initiation of clopidogrel therapy. Acute-phase reactants have been increased.

Clopidogrel appears to be somewhat more effective than aspirin if one is willing to accept a single paradigm of atherosclerosis. However, the benefit is modest: about 200 patients should use clopidogrel rather than aspirin for 1 year to prevent just one vascular event.

Other adverse GI effects reported in patients receiving clopidogrel include GI discomfort, diarrhea, constipation, dyspepsia, nausea, and abdominal pain, although the incidence is not known.

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