Desipramine Overview

Desipramine is a prescription medication classified as a tricyclic antidepressant (TCA). It is primarily used to treat depression by improving mood, sleep, appetite, and energy levels, and helping individuals regain interest in daily activities. Desipramine is available in tablet form and is known by its brand name Norpramin.

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How Desipramine Works

Desipramine works by restoring the balance of a natural substance called norepinephrine in the brain. This neurotransmitter is involved in regulating mood and emotions.

How to Use Desipramine HCL

  • Dosage: Take desipramine orally, usually 1 to 3 times a day as your doctor directs. The dosage depends on your medical condition and response to treatment. Your doctor may start with a low dose and adjust it gradually.
  • Administration: You can take desipramine with or without food. Your doctor may recommend taking the entire dose at once daily, either in the morning or before bedtime, depending on its effect on your sleep.
  • Effectiveness: It may take 2 to 3 weeks or longer for desipramine to exert its full effect when used to treat depression.

Side Effects of Desipramine

Common Side Effects

  • Drowsiness
  • Dizziness
  • Dry mouth
  • Blurry vision
  • Trouble urinating
  • Constipation
  • Vomiting
  • Loss of appetite
  • Sexual problems
  • Dry or burning eyes
  • Fast heart rate
  • High blood pressure

Serious Side Effects

  • QT Prolongation: This can lead to a serious irregular heartbeat. Notify your doctor immediately if you experience symptoms like fainting, fast/irregular heartbeat, or dizziness.
  • Adrenal Insufficiency: Symptoms include low blood pressure, fainting, dizziness, and fatigue.
  • Allergic Reactions: Seek immediate medical help if you notice symptoms such as trouble breathing or swelling of the throat.

Precautions and Considerations

  • Allergies: Inform your doctor about any allergies to desipramine or other tricyclic antidepressants (e.g., imipramine, amitriptyline).
  • Medical History: Disclose your medical history, especially if you have conditions like breathing problems, glaucoma, diabetes, heart issues, liver or kidney problems, seizures, thyroid disorders, or a history of mood disorders.
  • Pregnancy and Breastfeeding: Desipramine should not be used during pregnancy as it may harm the unborn baby. Consult your doctor before breastfeeding while using desipramine.

Interactions: Discuss all medications, including over-the-counter drugs and supplements, with your doctor to avoid interactions that could affect the effectiveness or safety of desipramine.

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Desipramine vs. Amitriptyline

Desipramine Amitriptyline
Prescription medication used to treat depression (Norpramin) Tricyclic antidepressant used for depression and various pain syndromes (Elavil)
Improves mood, sleep, appetite, energy levels Enhances levels of natural substances in the brain for mental balance
Restores balance of norepinephrine Increases levels of neurotransmitters involved in mood regulation

Both desipramine and amitriptyline belong to the same class of medications but are prescribed for different conditions. Desipramine specifically focuses on treating depression and related symptoms, while amitriptyline is used for a broader range of conditions including depression and various chronic pain syndromes.

Always follow your doctor's instructions carefully when taking desipramine


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Frequently Asked Questions

1. What is desipramine used to treat?

It is a medication used to treat depression. This medication may improve your mood, sleep, appetite, and energy level, as well as help you regain interest in your daily activities. This medication is in a class of drugs known as tricyclic antidepressants.

2. How long does it take for desipramine to work?

It might take 2 to 3 weeks for you to get the benefits from this medication. Even if you feel fine, keep taking it. Do not discontinue this without first consulting your doctor.

3. How long does desipramine stay in your system?

The half-life of this medicine, a tricyclic antidepressant, ranges from 12 to 54 hours. It is imipramine's pharmacologically active metabolite. Both substances bind to plasma proteins up to 95% of the time.

4. Can desipramine cause high blood pressure?

This medication may cause significant increases in pulse rate, reclining systolic and diastolic blood pressures, and orthostatic hypotension. These effects were immediately apparent during the first week of treatment and remained relatively consistent for the next five weeks.

5. Can desipramine cause insomnia?

Imipramine and desipramine have been linked to insomnia and increased sleep disruption. TCAs that cause sedation include doxepin, amitriptyline, and trimipramine.

6. Does desipramine help you sleep?

This medication helps in improving your sleep, mood, appetite, and energy level.

7. Is desipramine used for stomach issues?

It could be used in patients with constipation for abdominal pain while simultaneously treating constipation with other agents.

8. Does desipramine cause constipation?

This medication has the potential to cause constipation. Attempt to have a bowel movement every 2 to 3 days. If you haven't had a bowel movement in three days, contact your doctor or a healthcare professional.

9. Does desipramine cause hair loss?

Yes, it may cause hair loss because the side effects can lead to loss of hair.

10. Is desipramine used for pain?

This medicine is a tricyclic antidepressant that is used for treating neuropathic pain.


Disclaimer: The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.

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