What is Desloratadine?
Desloratadine is a second-generation tricyclic antihistamine that functions as a potent H1 antagonist in the peripheral nervous system. It's loratadine’s active descarboethoxy metabolite (second-generation histamine). Since desloratadine does not readily reach the central nervous system, it has a long-lasting effect and does not cause drowsiness.
It is available as a tablet, a disintegrating tablet, or an oral syrup. Both forms are taken orally. Clarinex is a brand-name drug that contains desloratadine. It can also be obtained as a generic drug.
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What are Desloratadine uses?
Desloratadine is used to treat hay fever and allergy symptoms in adults and children. These symptoms include:
- Sneezing
- Runny nose
- Swollen, itchy, weeping eyes
- Itching and rash associated with urticaria (hives; red, itchy raised areas of the skin).
Desloratadine Side Effects
Some of the common side effects of Desloratadine are:
Some of the serious side effects of Desloratadine are:
- Skin rash
- Itching
- Hives
- Swelling of the lips, tongue or throat
Most people don't have significant side effects. If you notice any effects, contact your doctor immediately.
Precautions to Take Before Using Desloratadine
- Consult your doctor if you have allergies to Desloratadine or any other medications.
- Discuss any medical history, including kidney disease, liver disease, abdominal pain, or stomach ulcers, with your doctor.
- Be aware that Desloratadine products may contain inactive ingredients that could trigger severe allergic reactions or other problems.
How to take Desloratadine?
Take Desloratadine as advised by the doctor
- Available in three forms: pill, oral solution (liquid), and orally disintegrating tablet
- Taken once daily, with or without food
- Use a dropper or oral syringe to dose the solution
Dosage of Desloratadine:
Missed Dose:
- If you miss a dose, take it as soon as you remember.
- If it's close to the time for your next dose, take only one dose. Do not double up to make up for missed doses, as it could be dangerous.
Overdose:
- Accidental overdose can occur if you take more than the prescribed amount of Desloratadine tablets.
- Overdose can lead to medical emergencies and harmful effects on the body's functions.
Interactions
Drug interactions can affect how medications work or increase the risk of serious side effects.
Examples of drugs that may interact with Desloratadine include:
- Disopyramide
- Anticholinergics (such as atropine, belladonna alkaloids, and scopolamine)
- Certain blood pressure medications (like clonidine, guanadrel, and guanethidine)
- Digoxin
- Thyroid supplements
- Valproic acid
MAO inhibitors should not be used with Desloratadine due to the risk of serious, possibly fatal interactions. Avoid MAO inhibitors, and consult your doctor about the timing of Desloratadine use in relation to MAO inhibitors.
Warnings for some serious health conditions
Individuals with specific health conditions are more likely to experience the side effects. The health conditions include
How to Store Desloratadine?
- Keep away from heat, air, and light exposure, as these factors can damage it.
- Keep the medicine in a safe place that is out of reach of children.
- Keep the drug at room temperature, ideally between 68ºF and 77ºF (20ºC and 25ºC).
Desloratadin vs Cetrizine
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Frequently Asked Questions
Desloratadine rarely induces drowsiness at prescribed doses. Avoid driving or operating machinery until you're sure it's safe to do so.
Desloratadine treats hay fever, allergy symptoms (like sneezing, runny nose, and itchy eyes), and urticaria (hives) itching and rash.
Evening dosing of Desloratadine may provide better symptom relief than morning dosage due to its long half-life and peak serum level period.
Desloratadine can potentially increase blood pressure, particularly in individuals with hypertension.
Common side effects of Desloratadine include sore throat, dry mouth, muscle pain, and tiredness.
