What is Diltiazem?

Diltiazem is sold under the brand name Cardizem. It is a calcium channel blocker used to treat high blood pressure, angina, and certain heart arrhythmias. It may also be used for hyperthyroidism if beta-blockers cannot be used. Diltiazem is given orally or by injection into the veins.


Diltiazem Uses

Diltiazem is used to prevent pain in the chest (angina). It may help increase your exercise ability and decrease how often angina attacks occur. It is referred to as a calcium channel blocker.

Diltiazem works by relaxing blood vessels in your body and heart, lowering your heart rate. Blood can flow more easily, and your heart will work less hard to pump blood.

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How to Use Diltiazem (Oral Tablet)?

  • Take Diltiazem (Oral Tablet) orally before meals and bedtime as directed by your doctor.
  • Swallow the tablets; never split, crush, or chew your tablets.
  • The dosage is based on your medical condition, response to treatment, and other medications that you may be taking. Please tell your doctor and pharmacist about all the medicines you are using.
  • Use Diltiazem medicine regularly to make the most of it. To help you remember, use it every day at the same time.
  • Diltiazem tab must be taken regularly to prevent angina. When it occurs, it should not be used to treat angina. Use other medications (such as nitroglycerin sublingual) to relieve an angina attack as directed by your doctor.
  • Tell your doctor if your condition is getting worse (for example, your chest pain worsens or is more frequent).

Diltiazem Side Effects

Here is the list of side effects the Digitiazem table or injection might cause. We recommend using this medicine only on a cardiology doctor's prescription.

  • Body aches or pain
  • Congestion
  • Cough
  • Dryness or soreness of the throat
  • Fever
  • Hoarseness
  • Tender or swollen glands in the neck
  • Trouble swallowing
  • Voice changes
  • Chest pain or discomfort
  • Chills
  • Diarrhea
  • Difficult or labored breathing
  • Feeling faint, dizzy, or lightheaded
  • Feeling warmth or heat
  • Redness of the skin
  • A general feeling of discomfort or illness
  • Headache
  • Joint pain
  • Loss of appetite
  • Muscle aches and pains
  • Nausea
  • Shivering
  • Slow or irregular heartbeat
  • Sweating
  • Swelling of the hands, ankles, feet
  • Tightness in the chest
  • Trouble sleeping
  • Unusual tiredness or weakness
  • Vomiting
  • Blistering, peeling, or loosening of the skin
  • Itching
  • Hive-like swelling on the face
  • No heartbeat
  • Red or irritated eyes
  • Sores
  • Ulcers
  • White spots in the mouth
  • Sneezing
  • Stuffy nose
  • Acid or sour stomach
  • Belching
  • Constipation
  • Continuing buzzing noise in the ears
  • Degenerative disease of the joint
  • Difficulty with moving
  • Hearing loss
  • Heartburn
  • Indigestion
  • Lack or loss of strength
  • Muscle aching or cramping
  • Muscle pains or stiffness
  • Tenderness around the eyes and cheekbones
  • Rash
  • Stomach discomfort, upset, or pain
  • Swollen joints

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Precautions to Take While Using Diltiazem

  • Tell your doctor or pharmacist if you are allergic to it before taking Diltiazem or having any other allergies. This product might have a few inactive ingredients that cause allergic reactions or other problems.
  • Tell your doctor or pharmacist about your medical history before using this medicine, particularly certain types of heart rhythm problems (such as sick sinus/atrioventricular block), liver disease, kidney disease, and heart failure.
  • Avoid drinking alcohol when taking this drug. You may get dizzy with this, and alcohol can make you a little more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely.
  • Before having surgery, tell your cardiologist that you are taking this medicine.
  • Older adults may be more sensitive than others to the side effects of this drug, especially dizziness, constipation, or swelling of the ankles/feet.

Diltiazem Drug Interactions With Other Medicine

  • Drug interactions may change the way your medications work or increase your risk of more serious effects.
  • You need to start, stop, or change the dosage of any medicine with your doctor's recommendation.
  • Some products that may interact with this drug include digoxin and fingolimod.
  • Other medications can possibly affect the removal of Diltiazem, which may affect how this medicine works. Examples include cimetidine, St. John's wort, azole antifungals such as ketoconazole, macrolide antibiotics such as erythromycin, rifamycin including rifabutin, and rifampin.
  • This medicine might slow down the removal of other drugs from your body, which might affect how they work.
  • Some products have ingredients that could increase your heart rate or cause more chest pain. Tell your pharmacist what products you are using and ask how to use them safely (especially cough and cold products, dietary aids, or NSAIDs such as ibuprofen/naproxen).

Diltiazem vs Digoxin

Diltiazem Digoxin
Diltiazem is sold under the brand name Cardizem Digoxin is sold under the brand name Lanoxin
Formula: C22H26N2O4S Formula: C41H64O14
Diltiazem is used to prevent pain in the chest (angina). It may help to increase your ability to exercise and decrease how often angina attacks may occur. Digoxin is a medication used in the treatment of various heart conditions.
Drug class: nondihydropyridine calcium channel blocker Digoxin belongs to the class of medicines that is called digitalis glycosides.

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Frequently Asked Questions

1. What is the use of Diltiazem?

Diltiazem is a medicine used to treat high blood pressure. If you have high blood pressure, it helps prevent future heart disease, heart attacks, and strokes. It is also used to prevent chest pain caused by angina and Raynaud's phenomenon

2. What is the side effect of Diltiazem?

A few side effects are -

  • Body aches or pain
  • Congestion
  • Cough
  • Dryness or soreness of the throat
  • Fever
  • Hoarseness
  • Runny nose
  • Tender or swollen glands in the neck
  • Trouble swallowing

3. Should you take Diltiazem in the morning or at night?

Adults at first, 180 to 240 milligrams (mg) once a day, in the morning or at bedtime. Your doctor might suggest a dose if necessary. For Children, Use and dose should be determined by your doctor only.

4. Is Diltiazem hard on the kidneys?

If it continues long, the heart and arteries may not function correctly. Diltiazem might damage the blood vessels in the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure.

5. Does Diltiazem affect sleep?

Diltiazem (Verapamil) has no data indicating sleep disturbance. Although sleep disturbance is identified as a potentially adverse effect on verapamil labeling the product, it is not known to have a common side effect occurring in less than 1% of the patients treated.

6. Is Diltiazem used to treat atrial fibrillation?

Calcium channel blockers diltiazem (Cardizem) and Verapamil (Calan, Isoptin) are effective for initial ventricular control in patients with atrial fibrillation. These agents are administered intravenously at bolus doses until the ventricular rate is slower.

7. How fast is Diltiazem starting to work?

Diltiazem controls high blood pressure and pain in the chest (angina) but does not cure it. It can take up to 2 weeks before you feel the full benefit of Diltiazem.

8. Can Diltiazem cause blurred vision?

Hypotension (low blood pressure) may occur while you are taking Diltiazem. Check with your doctor immediately if you have the following symptoms: Blurred vision, confusion, severe dizziness, faintness, or lightheadedness when you get up from a lying or sitting position suddenly, sweating, or unusual tiredness or weakness.

9. Can Diltiazem cause heart failure?

If it continues long, the heart and arteries may not function correctly. It can lead to damage in the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure.

10. Is Diltiazem safe long-term?

No adverse effects on urinalysis, hematological values, protein, lipid and glucose metabolism, renal or hepatic function, or electrolyte function have been observed for long-term administration of Diltiazem. It is therefore concluded that diltiazem hydrochloride can be administered safely to patients with hypertension for a long period.

11. Does Diltiazem raise blood sugar?

Diltiazem may cause an increase in blood sugar levels, and glucose tolerance may vary. People with diabetes may find it necessary to monitor their blood sugar more frequently while taking this medicine.


Disclaimer: The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.

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