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What is Domperidone?

Domperidone is a medicine that belongs to a class of drugs known as dopamine receptor antagonists. Domperidone works by blocking dopamine receptors in the stomach and upper intestine. This action boosts the movement of food through the digestive system, easing symptoms like nausea, vomiting, bloating, and discomfort.

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Uses of Domperidone

  • Domperidone is used to treat gastrointestinal motility disorders like gastroparesis.
  • It helps relieve symptoms such as nausea, vomiting, bloating, and discomfort.
  • It works by increasing the movement of food through the digestive system.
  • In some countries, it may also be used to alleviate symptoms of GERD, such as heartburn and regurgitation.

Domperidone Side Effects

Precautions

  • Take Domperidone before meals as directed by your doctor.
  • Avoid alcohol while using Domperidone.
  • Do not exceed seven days of Domperidone use without consulting your doctor.
  • Avoid use in children under 12 years old or weighing less than 35 kg.
  • Use caution in elderly patients over 65 years old; dosage adjustments may be needed.
  • Use in pregnant women only if benefits outweigh risks; consult a doctor first.
  • Avoid use in breastfeeding mothers due to potential adverse effects on the infant.

General Warnings

  • Inform your doctor about all current medications, including herbs and supplements, before starting Domperidone.
  • Inform your doctor if you develop watery diarrhea, a fever, or persistent stomach pain.
  • Use Domperidone cautiously if you have a history of cardiovascular diseases; close monitoring may be necessary.
  • Exercise extreme caution if you have electrolyte imbalances; regular monitoring of electrolyte levels is advised.
  • Domperidone may affect prolactin levels, potentially disrupting menstrual cycles in women and causing breast-like growth in men.
  • Use Domperidone for the shortest duration and at the lowest effective dose possible. Avoid self-administration.

Interactions

  • Take before a meal, ideally 15-30 minutes beforehand.
  • Discuss drug interactions with your doctor before starting any medication.

Dosage

  • The specific dosage can vary based on individual circumstances and the condition being treated.
  • The dosage of Domperidone typically ranges from 10 mg to 20 mg taken up to three times a day, usually before meals.

Missed Dose:

  • If a dose is missed, take it as soon as remembered.
  • If nearing the next scheduled dose, skip the missed one.
  • Resume a regular dosing schedule; do not double up.

Overdose:

  • If overdose symptoms like passing out occur, seek medical help.
  • Never exceed the prescribed dosage.

Storage:

  • Store at room temperature.
  • Keep away from direct sunlight, heat, and moisture.
  • Avoid storing it in the bathroom.
  • Keep out of reach of children.

Domperidone vs Metoclopramide

Domperidone Metoclopramide
Domperidone 10 MG Tablet is an effective anti-emetic used for relieving nausea and vomiting Metoclopramide is a medication that is used to treat stomach and esophageal issues.
Domperidone is used in the treatment of, nausea, indigestion, and vomiting. It is commonly used to treat and prevent nausea and vomiting, to aid in stomach emptying in people with delayed stomach emptying, and to aid in the treatment of gastroesophageal reflux disease. It is also utilized in the treatment of migraine headaches.
It acts on the part of the brain that controls vomiting. It also acts on the upper digestive tract to increase stomach and intestine movement, allowing food to pass more easily through the stomach. Metoclopramide works by inhibiting a naturally occurring substance (dopamine). It hastens stomach emptying and upper intestine movement.

Citations

Domperidone Use of domperidone in the treatment of canine visceral leishmaniasis: A clinical trial

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Frequently Asked Questions

Domperidone is generally safe, but consult your doctor, especially if you have heart issues or take other medications. Use the lowest effective dose and discontinue when no longer needed.

Avoid Domperidone if you have severe liver problems, conditions affecting heart rhythm, or underlying heart disease like congestive heart failure.

Domperidone is a D2-receptor antagonist that improves motility and gastric emptying. It shortens the time between meals and is thus used to treat regurgitation and vomiting.

Yes, Domperidone can be effective for bloating; it works by increasing gut motility and helping alleviate bloating and related symptoms.

Domperidone is a medication that is used to treat feelings of sickness (nausea) or being sick (vomiting). Feeling sick is a common symptom, but it can be caused by a variety of factors.

Domperidone works by speeding up the passage of food through the stomach and digestive tract, reducing feelings of bloating, fullness, and indigestion. It also works by inhibiting the action of a chemical in your brain that causes nausea and vomiting.

Domperidone can affect the heart by causing a heart rhythm disorder known as QT prolongation. This condition can lead to serious and sometimes fatal fast or irregular heartbeat.

Yes, it can make you feel sleepy.

Yes, some people might experience side effects of this medicine, including weight gain.

Uses Sideeffects Precautions Dosage Frequently Asked Questions
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