What is Doripenem?
Doripenem is a prescription antibiotic that treats severe bacterial infections related to kidneys, urinary tract, and stomach. It belongs to the class of medicines known as carbapenems. These function by interacting with bacteria's ability to form a cell wall.
Doripenem Uses
Doripenem injection is used to treat severe bacterial infections of the urinary tract, kidneys, and abdomen. The Food and Drug Administration (FDA) has not approved doripenem injection for treating pneumonia in people who were on a ventilator in a hospital. These antibiotics don’t work for any viral infections like colds and flu. Taking antibiotics when it is not needed may increase the risk of getting an infection that resists antibiotic treatment.
Side Effects
Some of the common & major side effects of Doripenem are:
- Vomiting
- Headache
- Nausea
- Diarrhea
- Redness or pain in the injection site
- Hives
- Itching
- Rash
- Blisters of the skin
- Sloughing of the skin
- Fever
- Difficulty while breathing
- Seizures
- Excessive tiredness
- Weakness
- Shortness of breath
- Pale skin
While a person is under the treatment of this drug they might experience certain side effects that may not be adverse. But if your reactions persist or worsen over time then contact your doctor immediately.
Precautions
Talk with your doctor if you are allergic to Doripenem or any other medications related to it. The product may contain some inactive ingredients which can cause some serious allergic reactions or some other serious problems. Before using the medications talk to your doctor if you are having any other medical history such as Kidney disease, seizures and stroke. The drug can cause live bacterial vaccination not to work properly. Avoid taking any immunization or vaccination while you are using any medication unless your doctor advises you to. Kidney function may decline as you grow older. So the older adults are at greater risk and can get adverse effects while you are using this drug.
How to use Doripenem?
- Doripenem injection is administered intravenously as a liquid (into a vein). It's usually issued every eight hours. The length of your treatment will be determined by the type of infection you have. After your condition has improved, your doctor may change the medication to a different antibiotic that can be taken orally. You can get a doripenem injection in a hospital. If you're using injection at home, make sure to take it at the same time each day.
Dosage
- For the treatment of Intraabdominal infection, Pyelonephritis and urinary tract infections
- 500 mg IV infusion in every 8 hours
- Duration therapy: 5 to 14 days
Missed Dose
As soon as you remember, take the missing dose. If it’s time for the next dose, skip the missed dose and return to the daily dosing schedule. To make up for a missed dose, do not take a double dose as it can result in some serious adverse effects
Overdose
You may experience symptoms such as stomach ache, nausea, and vomiting if you accidentally took too much of this medication. If you have taken an overdose of the drug, contact your doctor right away or go to the nearest hospital.
Warnings for serious Health Conditions
- Pregnancy & Breastfeeding:
- Doripenem is classified as a pregnancy category C drug. However, when no other options are available, the advantage of using it could outweigh the risk of not treating a serious infection in a pregnant woman. Consult with your doctor before taking any kind of medications during pregnancy.
- There is no evidence of doripenem while breastfeeding. Its excretion into breast milk is likely to be close to that of imipenem and meropenem, which contain low levels in milk and are unlikely to affect breastfed babies. So before taking any kind of medications talk to your doctor while breastfeeding.
Storage
- Direct contact with heat, air and light may damage your medicines. Exposure to medicine may cause some harmful effects. The medicine must be kept in a safe place and out of children’s reach.
- Mainly the drug should be kept at room temperature between 68ºF and 77ºF (20ºC and 25ºC).
Citations
Doripenem
Comparative activity of doripenem and three other carbapenems tested against Gram-negative bacilli with various β-lactamase resistance mechanisms