What is Droperidol?

Droperidol is a butyrophenone derivative with pharmacological properties similar to haloperidol. It is used in various medical settings, often in combination with opioid analgesics, to induce a state of neuroleptanalgesia, where the patient remains relaxed and unaware of their surroundings but still cooperative. Additionally, it is utilized as a premedicant, an antiemetic, and for managing agitation in acute psychosis.


Droperidol Uses

Droperidol serves multiple purposes:

  • Sedation: Used to sedate patients undergoing surgery or medical procedures.
  • Antiemetic: Helps reduce nausea and vomiting associated with surgical or diagnostic procedures.
  • Tranquilizer: Employed to manage agitation in patients with acute psychoses.

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Droperidol Side Effects

Common Side Effects:

Serious Side Effects:

Seek immediate medical attention if you experience:

  • Shortness of breath
  • Severe dizziness or fainting
  • Slow heart rate
  • Hallucinations
  • Bronchospasm
  • Severe nervous system reactions

Common side effects usually do not require medical attention and may subside as your body adjusts to the medication. However, serious or rare side effects necessitate immediate medical intervention.


Precautions

Before taking Droperidol, discuss the following with your doctor:

  • Allergies: Inform your doctor if you are allergic to Droperidol or similar medications.
  • Medical History: Disclose any history of congestive heart failure, irregular heartbeats, high blood pressure, electrolyte imbalance, liver or kidney disease, and adrenal gland tumors.
  • Long QT Syndrome: This medication should be avoided in individuals with this condition.

How to Use Droperidol

Droperidol should be used exactly as directed by a healthcare professional. It is typically administered 30 to 60 minutes before surgery, either intramuscularly (IM) or intravenously (IV). Additional doses may be administered based on the patient's condition and response to the initial dose. Vital signs and kidney function will be closely monitored post-injection.


Adult Dosage:

  • Initial dosage: 2.5 mg IM.
  • If necessary, additional doses of 1.25 mg can be administered to manage severe effects.

Missed Dose

Since Droperidol is administered by a healthcare provider, missed doses are generally not a concern. If you miss a scheduled appointment, contact your healthcare provider to reschedule.


Overdose

Overdose of Droperidol can lead to serious side effects such as:

  • Irregular heartbeat
  • Breathing difficulties
  • Severe dizziness
  • Fainting

Seek immediate medical attention if an overdose is suspected.


Warnings for Serious Health Conditions

Pregnancy & Breastfeeding:

  • Pregnancy: Use Droperidol only in emergencies and with the doctor's approval. Discuss potential risks and benefits with your doctor.
  • Breastfeeding: If the medication passes into breast milk, it may cause adverse reactions in the infant. Consult your doctor before use.

Storage

Keep Droperidol away from direct heat, air, and light to prevent degradation. Store it at room temperature, between 68ºF and 77ºF (20ºC and 25ºC), and keep it out of children's reach.

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Droperidol vs Ondansetron

Droperidol

Ondansetron

Class: Butyrophenone, similar to haloperidol

Class: Serotonin 5-HT3 receptor antagonist

Uses: Sedation, antiemetic, tranquilizer for agitation in acute psychoses

Uses: Antiemetic for nausea and vomiting caused by chemotherapy, radiation therapy, or surgery

Common Side Effects: Irregular heart rate, drowsiness, dizziness, restlessness, anxiety

Common Side Effects: Headache, fatigue, constipation, inadequate oxygenation, sleeplessness

Droperidol is a versatile medication used in various medical settings to sedate patients, reduce nausea and vomiting, and manage agitation in acute psychosis. Its administration and dosage should be closely monitored by healthcare professionals to ensure patient safety and efficacy. Always consult your healthcare provider for specific medical advice related to Droperidol use.


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Frequently Asked Questions

1. What is droperidol used for?

Droperidol is a sedative, tranquilizers and anti-nausea medicine that is used for reducing nausea and vomiting caused due to surgery or other medical procedures.

2. What class of drug is droperidol?

Droperidol is an antidopaminergic drug that is used as an antiemetic. It helps to control nausea and is often used as a sedative in intensive care treatment.

3. Is droperidol a controlled substance?

It belongs to the benzimidazole family and is both an organofluorine compound and an aromatic ketone. The DEA classifies Innovar as a Schedule II controlled drug.

4. How long does droperidol stay in your system?

The effects of the tranquilizer and sedatives last two to four hours on average, while changes in alertness can last up to twelve hours.

5. Does droperidol cause QT prolongation?

Droperidol is a sedative and anti-emetic that is extremely powerful. Because of concerns regarding QT prolongation and torsades de pointes, it has been excluded or severely limited. There is limited published evidence that droperidol induces QT prolongation outside of random news.

6. What are the side effects of droperidol?

Some of the common side effects of Droperidol are:

  • Irregular heart rate
  • Drowsiness
  • Dizziness
  • Feeling restless


Disclaimer: The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.

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