What is Fluorouracil?
Fluorouracil is an antimetabolite antineoplastic (anti-cancer) that is involved in palliative treatment such as:
- Colon
- Breast
- Ovary
- Liver
- Pancreatic
- Rectal
- Stomach cancer.
It interferes with DNA synthesis by blocking the conversion of deoxyuridylic acid to thymidylic acid by thymidylate synthetase. Fluorouracil is available under the brand name Adrucil.
Fluorouracil Uses
- Fluorouracil cream and topical solution are used to treat actinic or solar keratoses and superficial basal cell carcinoma, a type of skin cancer.
- This belongs to the class of medications called antimetabolites. This works by killing fast-growing cells, such as the abnormal cells in actinic keratoses and basal cell carcinoma.
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Fluorouracil Side Effects
Some of the common side effects of Fluorouracil are:
- Burning
- Crusting
- Redness
- Discoloration
- Irritation
- Pain
- Itching
- Rash
- Soreness
Some of the serious side effects of Fluorouracil are:
- Severe stomach ache
- Blood in diarrhea
-
Vomiting
-
Fever
- Chills
- Severe red skin rash
Talk with your doctor if you are having any if these side effects. Getting serious allergic reactions are very rare. However, seek medical attention if you are noticing any of the above symptoms.
Precautions
Before using Fluorouracil talk with your doctor if you are having an allergic reaction to it or any other medications.
The product may contain some inactive ingredients which can cause some serious allergic reactions or some other serious problems.
The medication should not be used if you have any medical conditions.
Before taking Fluorouracil, talk with your doctor if you have any medical history, such as:
- Enzyme deficiency
- Red or irritated skin
- Open sores on the skin
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How to take Fluorouracil?
- Fluorouracil comes in the form of a solution and a cream, which should be applied to the skin. It is usually applied to the affected areas twice a day.
- If you are treating actinic or solar keratosis with fluorouracil, you can continue to use it until the lesions begin to peel off. Usually, this takes 2 to 4 weeks or so.
- However, the lesions cannot be fully cured until 1 or 2 months after you stop using fluorouracil.
- If you are treating actinic or solar keratosis with fluorouracil, you can continue to use it until the lesions start to peel off. Usually, this takes about 2 to 4 weeks.
- However, just 1 or 2 months after you stop using fluorouracil, the lesions cannot be fully cured.
Missed Dose
If a dose is missing, use it as soon as possible. If the time for the next dose is close, skip the skipped dose. Use the next dose at a normal time. To catch up, keep the dose the same.
Overdose
Overdose of a drug can be accidental. If you have taken more than the prescribed Fluorouracil tablets, there is a chance of getting a harmful effect on your body’s functions. Overdose of a medicine can lead to some medical emergency.
Storage
- Direct contact with heat, air and light may damage your medicines. Exposure to medicine may cause some harmful effects. The medicine must be kept in a safe place and out of children’s reach.
- Mainly, the drug should be kept at room temperature between 68ºF and 77ºF (20ºC and 25ºC).
Fluorouracil Vs Imiquimod