What is Fluorouracil?

Fluorouracil is an antimetabolite antineoplastic (anti-cancer) that is involved in palliative treatment such as:

  • Colon
  • Breast
  • Ovary
  • Liver
  • Pancreatic
  • Rectal
  • Stomach cancer.

It interferes with DNA synthesis by blocking the conversion of deoxyuridylic acid to thymidylic acid by thymidylate synthetase. Fluorouracil is available under the brand name Adrucil.


Fluorouracil Uses

  • Fluorouracil cream and topical solution are used to treat actinic or solar keratoses and superficial basal cell carcinoma, a type of skin cancer.
  • This belongs to the class of medications called antimetabolites. This works by killing fast-growing cells, such as the abnormal cells in actinic keratoses and basal cell carcinoma.

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Fluorouracil Side Effects

Some of the common side effects of Fluorouracil are:

  • Burning
  • Crusting
  • Redness
  • Discoloration
  • Irritation
  • Pain
  • Itching
  • Rash
  • Soreness

Some of the serious side effects of Fluorouracil are:

Talk with your doctor if you are having any if these side effects. Getting serious allergic reactions are very rare. However, seek medical attention if you are noticing any of the above symptoms.


Precautions

Before using Fluorouracil talk with your doctor if you are having an allergic reaction to it or any other medications.

The product may contain some inactive ingredients which can cause some serious allergic reactions or some other serious problems.

The medication should not be used if you have any medical conditions.

Before taking Fluorouracil, talk with your doctor if you have any medical history, such as:

  • Enzyme deficiency
  • Red or irritated skin
  • Open sores on the skin

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How to take Fluorouracil?

  • Fluorouracil comes in the form of a solution and a cream, which should be applied to the skin. It is usually applied to the affected areas twice a day.
  • If you are treating actinic or solar keratosis with fluorouracil, you can continue to use it until the lesions begin to peel off. Usually, this takes 2 to 4 weeks or so.
  • However, the lesions cannot be fully cured until 1 or 2 months after you stop using fluorouracil.
  • If you are treating actinic or solar keratosis with fluorouracil, you can continue to use it until the lesions start to peel off. Usually, this takes about 2 to 4 weeks.
  • However, just 1 or 2 months after you stop using fluorouracil, the lesions cannot be fully cured.

Missed Dose

If a dose is missing, use it as soon as possible. If the time for the next dose is close, skip the skipped dose. Use the next dose at a normal time. To catch up, keep the dose the same.

Overdose

Overdose of a drug can be accidental. If you have taken more than the prescribed Fluorouracil tablets, there is a chance of getting a harmful effect on your body’s functions. Overdose of a medicine can lead to some medical emergency.


Storage

  • Direct contact with heat, air and light may damage your medicines. Exposure to medicine may cause some harmful effects. The medicine must be kept in a safe place and out of children’s reach.
  • Mainly, the drug should be kept at room temperature between 68ºF and 77ºF (20ºC and 25ºC).

Fluorouracil Vs Imiquimod

Fluorouracil Imiquimod
Fluorouracil is an antimetabolite antineoplastic (anti-cancer) that is involved in the palliative treatment of colon, breast, ovary, liver, pancreatic, rectal, and stomach cancer. Imiquimod belongs to a category of drugs called modifiers of immune responses. It is believed to function to combat these irregular skin growths by helping to activate the immune system.
Fluorouracil cream and topical solution are used for treating actinic or solar keratoses. The cream and solution is used for treating a type of skin cancer called superficial basal cell carcinoma. Imiquimod is used to treat precancerous growths in the skin caused by actinic keratosis (AK). Too much exposure to the sun triggers AK.
Some of the common side effects of Fluorouracil are:
  • Burning
  • Crusting
  • Redness
  • Discoloration
  • Irritation
Some of the common side effects of Imiquimod are:
  • Redness
  • Itching
  • Burning
  • Flaking
  • Scaling
  • Swelling
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Frequently Asked Questions

1. How long does it take for fluorouracil cream to work?

This normally takes at least 3 to 6 weeks but can take up to 10 to 12 weeks to complete. The skin lesions and surrounding areas will feel irritated during the first few weeks of therapy and appear red, swollen, and scaly. This is an indication that it operates with fluorouracil.

2. What are the side effects of fluorouracil?

Some of the common side effects of Fluorouracil are

  • Burning
  • Crusting
  • Redness
  • Discoloration
  • Irritation

3. Does fluorouracil cream affect healthy skin?

This is a sun-induced pre-cancerous growth of the skin. Fluorouracil responds to pre-cancerous skin damaged by the light but typically does not affect normal skin. It is a skin cream applied to the skin.

4. How do you know when to stop fluorouracil?

The damaged skin becomes sore and inflamed with a beefy-red appearance with erosion and crusting after continued application. The prescription should be stopped at this stage.

5. Do you rub in fluorouracil cream?

After washing the face with clean water, fluorouracil cream is applied once or twice a day. A small amount of the cream should be gently rubbed with a fingertip into all of the treatment areas. Applying it to all the skin and not just visible lesions is necessary.


Disclaimer: The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.

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