What is Ganirelix ?
Ganirelix acetate is an injectable gonadotropin-releasing hormone (GnRH) antagonist. It is marketed under the brand names Orgalutran and Antagon. Primarily used in assisted reproduction, Ganirelix helps regulate ovulation by preventing premature egg release during fertility treatments.
Ganirelix Uses
Ganirelix is used in fertility treatments, specifically controlled ovarian stimulation. It is often combined with other hormones like FSH (follicle-stimulating hormone) and hCG (human chorionic gonadotropin). By blocking the release of luteinizing hormone (LH), Ganirelix prevents eggs from being released too early, allowing them to mature properly.
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Get A Second OpinionHow to Use Ganirelix
- Read Instructions: Follow the leaflet or prescription instructions provided by your pharmacist or doctor.
- Preparation and Administration: Learn the preparation and administration steps from your healthcare professional.
- Check for Discoloration: Inspect the product for any discoloration or damage before use.
- Inject as Directed: Administer the injection under the skin as prescribed, typically once daily during a specific phase of your cycle.
- Clean Injection Site: Clean the injection site properly before each dose. Rotate sites to prevent skin injury.
- Follow Dosage Guidelines: Use the medication exactly as directed by your doctor, without increasing the dose or frequency.
How Does Ganirelix Work?
Ganirelix blocks GnRH receptors, quickly and reversibly suppressing the secretion of gonadotropins. It particularly suppresses LH more than FSH. After stopping Ganirelix, LH and FSH levels recover within 48 hours.
Ganirelix Side Effects
Common Side Effects:
- Mild nausea
- Stomach pain
- Headache
- Vaginal bleeding
- Pain or irritation at the injection site
Serious Side Effects:
- Severe pelvic pain
- Swelling of hands or legs
- Severe abdominal pain and swelling
- Shortness of breath
- Rapid weight gain
- Decreased urination
- Ovarian hyperstimulation syndrome (OHSS)
Allergic Reactions:
- Rash
- Itching/swelling (face/tongue/throat)
- Severe dizziness
- Difficulty breathing
If any serious side effects or allergic reactions occur, seek immediate medical help.
Precautions
Before using Ganirelix, inform your doctor if you have allergies, particularly to other GnRH products, or if you have any medical conditions. This medication may contain inactive ingredients that can cause allergic reactions or other problems.
Important Precautions:
- Multiple Births: There is a risk of multiple births.
- Pregnancy: Stop using Ganirelix if you become pregnant. It is not safe during pregnancy.
- Breastfeeding: Consult your doctor as it is unclear if Ganirelix passes into breast milk.
Interactions
Medication interactions can alter the effectiveness of Ganirelix or increase side effects. Inform your doctor about all medications you are taking, including prescription, nonprescription, and herbal products.
Dosage and Administration
Ganirelix 250 μg is usually administered subcutaneously once daily during the mid-to-late follicular phase of the menstrual cycle. Treatment continues until hCG administration, which triggers final follicle maturation. If the ovaries are overly stimulated, hCG may be withheld to minimize risk.
Missed Dose
If you miss a dose, take it as soon as you remember. Do not double up doses.
Overdose
In case of overdose, seek emergency medical help immediately. Symptoms can include severe side effects such as passing out or difficulty breathing.
Storage
Store Ganirelix away from direct heat, moisture, and sunlight. Keep it out of reach of children.
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Book an AppointmentGanirelix vs. Cetrorelix
|
Ganirelix |
Cetrorelix |
|---|---|
|
Brand names: Orgalutran, Antagon |
Brand name: Cetrotide |
|
Formula: C84H121ClN18O17 |
Formula: C70H92ClN17O14 |
|
GnRH antagonist used in combination with FSH and hCG |
GnRH antagonist used in combination with FSH and hCG |
|
Prevents premature release of eggs |
Prevents premature release of eggs |
Consultation and Emergency
Always consult your doctor before starting or stopping Ganirelix. In case of any side effects or health concerns, seek immediate medical assistance.
Medicover Call Center Number: 040-68334455
Follow your prescription and doctor's advice closely to ensure the best outcome from your treatment.
