Imipramine Overview

Imipramine is a prescription medication available in the form of oral tablets and oral capsules.
The oral tablet form of Imipramine is available as a brand name drug called Tofranil and also as a generic drug.
It is a tricyclic antidepressant used to treat depressive symptoms and nighttime bed-wetting (enuresis) in children 6 years and older.

Imipramine Uses

Treatment of Depression:

Enhances mood, sleep, appetite, and energy levels.
Helps regain interest in everyday living.

Treatment of Bed-Wetting in Children:

Helps control nighttime bed-wetting.
Blocks the effect of acetylcholine on the bladder.

How Imipramine Works

Imipramine belongs to the class of tricyclic antidepressants.
It restores the balance of certain natural substances in the brain, such as norepinephrine-like neurotransmitters.
For bed-wetting, it blocks the effect of acetylcholine on the bladder.

Imipramine Side Effects

Common Side Effects

Nausea
Drowsiness
Weakness or tiredness
Excitement or anxiety
Dry mouth
Increased skin sensitivity
Constipation
Difficulty urinating
Excessive sweating

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Serious Side Effects

Jaw, neck and back muscle spasms
Shuffling walk
Difficulty in swallowing and breathing
Rash
Yellowing of the skin
Irregular heartbeat

Note: Contact your doctor immediately if you experience serious side effects.

Precautions

Inform your doctor if you are allergic to Imipramine or any other medications.
The product may contain inactive ingredients that could cause allergic reactions or other problems.
Discuss your medical history with your doctor, particularly if you have:
- Breathing problems
- Glaucoma
- Diabetes
- Liver or kidney problems
- Seizures
- Overactive thyroid

How to Take Imipramine

Imipramine is taken by mouth as a tablet or capsule.
For depression, take it one or more times a day, with or without food.
For bed-wetting, take it one hour before bedtime. Children may need one dose in the mid-afternoon and another at bedtime.
Take Imipramine at the same time each day.
It may take 1-3 weeks or longer to experience the full benefits.
Do not stop taking Imipramine without consulting your doctor, who may need to reduce your dosage gradually.

Dosage Instructions To Follow

Drug Forms and Strengths

Generic: Imipramine
- Form: Oral tablet
- Strengths: 10 mg, 25 mg, 50 mg
Brand: Tofranil
- Form: Oral tablet
- Strengths: 50 mg

Missed Dose

Missing one or two doses may not have a significant effect.
If you miss a dose, take it as soon as you remember unless it is close to your next dose.
Do not double the dose to make up for a missed dose.

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Overdose

Overdose can be accidental and harmful.
If you take more than the prescribed amount, seek medical attention immediately.

Warnings for Serious Health Conditions

Bipolar Disorder: Imipramine may worsen mania symptoms.
Trouble Urinating: May worsen symptoms, consult your doctor.
Open-angle Glaucoma: May worsen the condition, your doctor will monitor your vision.
Seizure Disorder: May increase the number of seizures.
Heart Disease: May worsen the condition, especially if you have a history of heart disease, heart attack, stroke or rapid heartbeat.

Special Considerations

Pregnant Women: Not recommended by the FDA; safety and efficacy not established.
Breastfeeding: May transfer into breast milk and cause side effects in the child. Consult your doctor.

Storage

Keep at room temperature (68ºF to 77ºF / 20ºC to 25ºC).
Keep away from heat, air, and light.
Store in a safe place, out of reach of children and pets.
Do not flush down the toilet or pour into the sink; consult your pharmacist for disposal instructions.

Important Advice

Always consult your doctor before taking Imipramine.
In case of any problems or side effects, seek immediate medical attention.
Carry your medications while traveling to avoid emergencies.
Follow your prescription and doctor's advice when taking Imipramine.

Imipramine vs Amitriptyline

Imipramine	Amitriptyline
Imipramine is a medicine with a prescription. They come in the form of oral tablets and oral capsules. The oral tablet Imipramine is available as a brand name drug called Tofranil.	Amitriptyline is a tricyclic antidepressant with sedative effects. The medication affects a certain chemical messenger which communicates between brain cells and helps in regulating mood.
For the treatment of depression, Imipramine drug is used. It is also used in the treatment of nighttime bed-wetting (enuresis) in children with other therapies	Amitriptyline is used for the treatment of depressions. This belongs to the class of drugs called tricyclic antidepressants. The medication can also help in improving mood and feelings of well- being.
Some of the common side effects of Imipramine are: Nausea Drowsiness Weakness or Tiredness Excitement or anxiety Dry mouths Skin gets more sensitive	Most common side effects of Amitriptyline are: Nausea Vomiting Drowsiness Headaches Dry mouth

Citations

CLINICAL PHARMACOLOGY OF IMIPRAMINE AND RELATED ANTIDEPRESSANT COMPOUNDS

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Frequently Asked Questions

1. What are the side effects of imipramine?

There may be dry mouth, blurred vision, headache, drowsiness, dizziness, constipation, nausea, vomiting, loss of appetite, diarrhea, stomach cramps, loss of weight, and increased sweating. If any of these symptoms persist or worsen, immediately inform your physician or pharmacist.

2. Is imipramine a sedative?

Imipramine does not impact mood or arousal in non-depressed persons, but can induce sedation. Imipramine exerts a positive effect on mood in depressed individuals. TCAs are potent serotonin and norepinephrine reuptake inhibitors.

3. Is imipramine used for anxiety?

In treating panic disorder, PTSD, generalized anxiety, and depression that comes with anxiety, physicians use tricyclic antidepressants. Imipramine was the subject of several of the panic recovery trials in this family.

4. How quickly does imipramine work?

You will find it does not work for you right away when you start taking imipramine for depression. The impact will take a week or two to build up and 4-6 weeks before the full benefit is felt. It is important that you do not quit taking it, thinking that it does not help.

5. Can you just stop taking imipramine?

Before taking any other imipramine medications, consult with your doctor first. Do not quit taking this drug abruptly without consulting with your doctor first. Before stopping it entirely, your doctor may want you to progressively will the amount you are using.

6. Does imipramine help with pain?

Imipramine is a tricyclic antidepressant which is often used to treat chronic neuropathic pain (central nervous system (CNS) pain due to nerve damage or changes).

7. Does imipramine cause heart problems?

In patients with cardiovascular disease, 4 developed congestive heart failure during the administration of imipramine, while 10 of 411 experienced serious postural hypotension (24.4 percent). Two formed during a hypotensive phase of myocardial infarction.

Disclaimer: The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.