What is Lamotrigine?

Lamotrigine is a prescription medicine available in various forms, including immediate-release, extended-release, chewable, and orally disintegrating tablets. Brand names for lamotrigine include Lamictal, Lamictal XR, Lamictal CD, and Lamictal ODT, with generic versions also available.


Lamotrigine Uses:

  • Lamotrigine is used to prevent and manage seizures, either alone or in conjunction with other drugs.
  • It helps manage severe mood swings in adults with bipolar disorder.
  • Functions as an anticonvulsant and antiepileptic by rebalancing brain chemicals.
  • Not recommended for children under the age of two due to high risk of side effects.

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How to Use Lamotrigine?

  • Read the Prescription Guide and Patient Information Leaflet.
  • Take orally with or without food, swallow whole to avoid bitter taste.
  • Dosage varies based on medical condition and reaction.
  • Follow the doctor's dosing instructions carefully, dosage may need gradual increase.
  • Take daily at the same time to maximize benefits.
  • Do not stop taking abruptly; consult your doctor for gradual reduction if needed.

Lamotrigine Side Effects:

  • Common: Loss of balance, double vision, blurred vision, headache, dizziness, nausea, vomiting.
  • Less common: Weight loss, heartburn, stomach pain, back or joint pain, menstrual irregularities.
  • Serious: Allergic reactions, severe dizziness, and fainting (especially in older adults).

Precautions:

  • Inform your doctor if you have allergies, kidney disease, liver disease, or heart conditions.
  • Older adults may experience more severe side effects.
  • Discuss risks and benefits with your doctor if pregnant or breastfeeding.
  • Birth control efficacy may be reduced; consult about alternatives.

Interactions:

  • Be aware of potential interactions with hormonal birth control, estrogens, certain HIV drugs, rifampin, supplements, and herbs.
  • Ensure your doctor monitors all medications, vitamins, and herbs you are taking.

Overdose and Missed Dose:

  • In case of overdose, seek medical advice immediately.
  • If a dose is missed, take it as soon as remembered, but skip if the next dose is near.

Storage:

  • Store at room temperature, away from light and moisture.
  • Keep out of reach of children.
  • Dispose of properly when expired or no longer needed.

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Comparison: Lamotrigine vs Lithium

Lamotrigine Lithium
Used for managing epilepsy and bipolar disorder. Used for treating bipolar disorder and major depressive disorder.
Treats focal, tonic-clonic, and Lennox-Gastaut syndrome seizures. Reduces suicide risk in psychiatric conditions.
Can be used alone or with other drugs. Administered orally for psychiatric disorders like bipolar disorder, depression, and schizophrenia.
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Frequently Asked Questions

1. What is Lamotrigine used for?

Lamotrigine is used to treat epilepsy and to help prevent episodes of low mood (depression) in adults with bipolar disorder.

2. Does Lamotrigine help with anxiety?

No, Lamotrigine is not FDA-approved for the treatment of anxiety disorders.

3. What are the initial effects of taking Lamotrigine?

When starting Lamotrigine, some people may experience drowsiness or difficulty falling asleep. These effects should be discussed with a healthcare provider.

4. Does Lamotrigine improve mood?

Yes, Lamotrigine is known for improving mood by alleviating depressive symptoms rather than suppressing mania.

5. Does Lamotrigine cause weight gain?

No, Lamotrigine is unlikely to cause significant weight gain. Some individuals may experience minor weight loss.

6. Can Lamotrigine affect memory?

Lamotrigine may improve cognitive function, including aspects of memory, particularly in individuals with bipolar disorder.

7. Does Lamotrigine increase serotonin?

Lamotrigine has a mild effect on serotonin receptors but is not a direct serotonin enhancer or reuptake inhibitor.

8. Does Lamotrigine affect appetite?

While uncommon, changes in appetite may occur in some individuals taking Lamotrigine.

9. Can Lamotrigine worsen depression?

In some cases, Lamotrigine may not be suitable for individuals with severe depression, as it could potentially worsen symptoms.

10. How does Lamotrigine work in the brain?

Lamotrigine modulates neuronal excitability in the central nervous system, helping to control seizures and stabilize mood in bipolar disorder.


Disclaimer: The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.

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