What is Medroxyprogesterone?

Medroxyprogesterone injection is a prescription drug available under brand names like Depo-Provera, Depo-Provera CI, or Depo-subQ Provera 104. It is a progestin that helps regulate ovulation and menstrual cycles in women. The medication treats irregular or missing menstrual cycles, abnormal uterine bleeding, and reduces the risk of endometrial hyperplasia during estrogen hormone replacement therapy in postmenopausal women.


Medroxyprogesterone Uses

Medroxyprogesterone is a progestin hormone used for:

  • Treating irregular uterine bleeding.
  • Restoring regular menstrual cycles in women with amenorrhea.
  • Managing menopause symptoms in combination with estrogen therapy.

Medroxyprogesterone Side Effects

Common side effects may include:

Serious side effects can include:

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Precautions Before Using Medroxyprogesterone

Before using Medroxyprogesterone, inform your doctor if you:

  • Are allergic to it or any other medications.
  • Have a history of blood clots, internal bleeding, liver disease, cancer, vaginal bleeding, or seizures.
  • Discuss potential risks with inactive ingredients in the medication.

How to Use Medroxyprogesterone injection

  • Administered intramuscularly into the buttocks or upper arm by a healthcare provider every 13 weeks.
  • Subcutaneous injection available for administration just under the skin every 12 to 14 weeks.
  • For menstrual cycle management, take once daily for 5-10 days during the second half of the cycle, as directed by your doctor.

Withdrawal bleeding typically occurs 3-7 days after stopping the medication.


Dosage Instructions for Medroxyprogesterone

Missed Dose:

  • Missing one or two doses of medroxyprogesterone won't typically affect your body. However, consistent timing is important for the medication to work effectively. Missing a dose may cause sudden chemical changes in your body.

Overdose:

  • Accidentally taking more than the prescribed medroxyprogesterone tablets can have harmful effects on your body's functions and may lead to a medical emergency.

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Medroxyprogesterone Warnings for Health Conditions

For People with Blood Clots or Stroke:

Medroxyprogesterone increases the risk of blood clots. If you have a history of blood clots or stroke, consult your doctor before using this medication.

For People with Liver Problems:

Liver disorders can affect how medroxyprogesterone is processed in your body, potentially increasing its levels and leading to more side effects. Discuss with your doctor if you have liver problems or a history of liver disease.

Pregnant Women:

Medroxyprogesterone should not be used during pregnancy. If you become pregnant while taking this medication, contact your doctor immediately.

Breastfeeding:

Medroxyprogesterone can pass into breast milk and may cause problems for a breastfed infant. Consult your doctor if you are breastfeeding; you may need to stop breastfeeding or adjust your medication.

Storage Information

  • Store medroxyprogesterone at room temperature between 68ºF and 77ºF (20ºC and 25ºC).
  • Keep the medication in a safe place, protected from heat, air, and light to avoid potential damage.
  • Ensure the medicine is stored out of children's reach to prevent accidental ingestion.

Fondaparinux vs Heparin:

Medroxyprogesterone Norethisterone
Medroxyprogesterone is a progestin (a form of progesterone) that aids in the regulation of ovulation (the release of an egg from the ovary) and menstrual cycles in women. Norethisterone is a synthetic progestin. It works by imitating the effects of natural progesterone (female hormone). It helps to regulate the growth and shedding of the lining of the womb, thus treating menstrual irregularities.
Medroxyprogesterone is also used to treat menopause symptoms as part of a combined hormone replacement treatment with estrogens (e.g., hot flashes). This medicine is used to prevent pregnancy. It is often referred to as the "mini-pill" because it does not contain any estrogens.
Some of the common side effects of Medroxyprogesterone are:
  • Change in menstrual period
  • Weight gain
  • Weakness
  • Tiredness
  • Irritability
Some of the common and serious side effects of Norethindrone are:

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Frequently Asked Questions

1. What is medroxyprogesterone used for?

This drug is used to treat irregular uterine bleeding in women who are not pregnant or going through menopause, as well as to restore regular menstrual cycles in women who have not had them for many months (amenorrhea).

2. What are the side effects of medroxyprogesterone?

Some of the serious side effects of Medroxyprogesterone are:

  • Shortness of breath
  • Chest pain
  • Coughing
  • Blood clots
  • Stroke

3. How long does it take for medroxyprogesterone to work?

Starting on the 16th day of a 28-day oestrogen therapy course, you'll normally take 10mg every day for 10-12 days. Provera should start working 3 to 7 days after you start taking it. If you don't get your period after finishing a course of Provera, see your doctor if you're pregnant.

4. How long should I take medroxyprogesterone?

The doctor will adjust the dose as needed. However, the dosage shouldn’t be more than 10 mg per day. This is usually taken every day for 5 to 10 days.


Disclaimer: The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.

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