What is Misoprostol?

Misoprostol is a drug used for poor uterine contraction, it is used to prevent and treat stomach ulcers, initiate labor, cause abortion, and treat postpartum bleeding. It is marketed under the Cytotec name. It is used alone, either with mifepristone or methotrexate, for abortions.


What are the Misoprostol Uses?

This medication is used while you are taking NSAIDs (e.g. aspirin, ibuprofen, naproxen) to prevent stomach ulcers, particularly if you are at risk of developing ulcers or have a history of ulcers. 

Misoprostol helps to reduce the risk of serious complications from ulcers, such as bleeding. This drug protects the lining of your stomach by reducing the amount of acid that comes into contact with it.

This medication is also used to terminate a pregnancy in combination with another drug (mifepristone) (abortion).


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How to use

  • A patient data leaflet comes with this medicine. Read it thoroughly. Ask your doctor, nurse, or pharmacist if you have any questions concerning this drug.
  • The dosage is totally based on your medical conditions and your treatment responses.
  • Take it by mouth, usually four times a day, to minimize diarrhea and prevent stomach ulcers after meals and at bedtime, or as prescribed by your doctor.
  • Take it by mouth, exactly as directed by your doctor, if you are taking this abortion medication.
  • Your healthcare professional will insert it into your vagina if you are using this medication to start labor.
  • When using misoprostol, avoid taking magnesium-containing antacids because they may worsen the diarrhea it causes. Consult your physician or pharmacist if you need an antacid to help you choose a product.
  • Keep taking this medication for as long as you take NSAIDs for ulcer prevention. To get the most benefits from it, use this medication regularly.
  • If your condition continues to persist or worsens, please inform your doctor.

What are the Misoprostol Side Effects?

Misoprostol can cause adverse effects. Inform your doctor if any of the following symptoms:

If you experience any of the following symptoms, call your doctor immediately:

  • Vomiting Blood
  • Bloody Or Black, Tarry Stools

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What are the Precautions of Misoprostol?

  • Tell your doctor or pharmacist whether you are allergic to it, or whether you have any other allergies, before taking misoprostol
  • Tell your doctor or pharmacist your medical history before using this drug, in particular: stomach/intestinal disorder (e.g., inflammatory bowel disease).
  • Alcohol and tobacco consumption on a daily basis can increase your risk of stomach bleeding. Limit drinks made with alcohol and avoid smoking.
  • An incomplete abortion can rarely occur if you are taking this drug in conjunction with mifepristone to end a pregnancy. Being closely watched by your doctor and holding your regular appointments to track your progress is very important for you. In case of an emergency, make sure to have specific instructions from your doctor on who to contact and what to do. If you experience some unlikely symptoms, such as severe/prolonged vaginal bleeding, signs of infection (including fever, chills), or fainting, anticipate vaginal bleeding after you take the combined drug, but inform your doctor right away.
  • Owing to potential damage to an unborn infant, this medicine must not be used during pregnancy to avoid stomach ulcers. Using successful birth control measures when taking misoprostol and for at least one month or one completed menstrual cycle after you quit taking it if you are of childbearing age.
  • Inform your doctor right away if you become pregnant or think you might be pregnant.
  • It passes into breast milk with this drug. This medication is unlikely to affect a breastfeeding child, however. Before breastfeeding, consult the doctor.

What are the Interactions of Misoprostol?

  • Croelemer
  • Eluxadoline

There are no known mild interactions of misoprostol with other drugs.


Misoprostol Dosage

What should one do, if Dose is Missed?

If you forgot to take a dose, take it as soon as you remember.

How should one respond to an overdose of Misoprostol?

Do not take too much. It may cause you severe health issues. Do not take two doses at one time, maintain the time gap between the doses.

How to Store Misoprostol Medicine?

Keep away from sunlight and moisture in a dry position at or below 77 degrees F (25 degrees C). Unless directed to do so, do not flush drugs down the toilet or dump them into a drain. When it gets expired or no longer needed, properly discard this product.


Misoprostol vs Mifepristone

Misoprostol Mifepristone
Formula: C22H38O5 Formula: C29H35NO2
Brand name Cytotec Drug class- Antiprogestogen; Antiglucocorticoid
Molar mass: 382.5 g/mol Molecular Weight: 429.6 g/mol
Is a medicine used to prevent and treat stomach ulcers, start work, cause abortion, and treat postpartum bleeding due to poor contraction of the uterus. Is a medication that is used in combination with misoprostol to bring abortion during pregnancy.

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Frequently Asked Questions

1. What is Misoprostol prescribed for?

In people who take some arthritis or pain medications, including aspirin, that can cause ulcers, misoprostol is used to avoid ulcers. It preserves the lining of the stomach and reduces the secretion of stomach acid.

2. What does Misoprostol do to the uterus?

Fetal tissue and the uterine lining would be loosened by misoprostol. The uterus will contract and, within a few hours, the cervix will dilate. It will cause bleeding and cramping as the tissue moves through the body.

3. How quickly does Misoprostol work?

Cramping and bleeding triggers this drug to drain the uterus. Cramping and bleeding typically begin 1-4 hours after misoprostol is taken in most individuals.

4. Is Misoprostol taken orally or inserted?

For improved effectiveness, vaginal administration of misoprostol is recommended. The prescribed dose of misoprostol is vaginally injected at 800 mcg (4 200-mcg tablets). The results of the study have shown that vaginal administration is more successful than oral misoprostol usage.

5. Can Misoprostol damage the uterus?

During pregnancy, Cytotec can cause the uterus to tear (uterine rupture). As the pregnancy progresses and if you have undergone surgery on the uterus, such as Cesarean delivery, the risk of uterine rupture increases. Extreme bleeding, hysterectomy, and/or maternal or fetal death may result in uterine rupture (tearing).

6. How long does it take for Misoprostol to dissolve vaginally?

To allow the tablets to dissolve, lie down for about 30 minutes after you insert the misoprostol tablets. You can push them back in again if you notice the tablets falling out, or call us for instructions on what to do.

7. How long do the side effects of Misoprostol last?

The side effects are common, typically lasting just 1 to 4 hours. If any of these side effects make you very uncomfortable, over-the-counter medicines can treat your symptoms. If over-the-counter treatments do not ease the symptoms, call them.

8. Can Misoprostol affect future pregnancy?

Misoprostol therapy is an effective treatment with no adverse impact on potential fertility for women with a missed abortion in the first trimester and a favorable history of reproduction.

9. What not to do on misoprostol?

  • Do not take it during pregnancy: Misoprostol should not be taken if you are pregnant, as it can cause abortion or birth defects.
  • Avoid alcohol: Alcohol can increase the risk of gastrointestinal side effects when taken with misoprostol.
  • Avoid nonsteroidal anti-inflammatory drugs (NSAIDs): Combining misoprostol with NSAIDs can increase the risk of gastrointestinal bleeding.
  • Do not crush or chew: Misoprostol tablets should be swallowed whole with water and not crushed or chewed, as this can increase the risk of gastrointestinal irritation.

10. What is the duration of action of misoprostol?

  • The duration of action of misoprostol varies depending on the dosage and route of administration. When used for medical abortion, misoprostol is typically administered vaginally or buccally and can start to take effect within a few hours. Complete abortion may occur within a day or two after administration.
  • When used for the prevention of gastric ulcers in patients taking nonsteroidal anti-inflammatory drugs (NSAIDs), the duration of action can last up to 8 hours, providing protection to the gastrointestinal mucosa.


Disclaimer: The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.

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