Niclosamide: Uses, Side Effects and Precautions

Niclosamide, marketed under brand names like Niclocide, is an effective treatment for tapeworm infections such as diphyllobothriasis, hymenolepiasis, and taeniasis. It is taken orally and does not affect other types of worms, such as pinworms and roundworms.


Niclosamide Uses

  • Niclosamide is an anthelmintic, which means it kills parasitic worms. Anthelmintics are medications that are used to treat worm infections.
  • It is used to treat tapeworm infections such as large or fish tapeworm, dwarf tapeworm, and beef tapeworm.
  • Niclosamide can also be used to treat other tapeworm infections if your doctor recommends it. It is ineffective against other forms of worm infections (for example, pinworms or roundworms).
  • Niclosamide kills tapeworms when they come into contact with it. The destroyed worms are passed in the stool, although they may not always be visible in the stool.
  • Niclosamide requires a doctor's prescription.

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How to Use Niclosamide

  • Niclosamide can be taken without food (either 1 hour before or 2 hours after a meal). However, taking it after a light meal can help avoid stomach discomfort (e.g: breakfast).
  • Chew or crush Niclosamide tablets thoroughly before swallowing them whole with a small amount of water. For children, crush tablets into a fine powder and mix with a small amount of water to form a paste.
  • Follow your doctor's instructions carefully for the complete clearance of your infection. Typically, one dose is sufficient, but some patients may need a second dose to fully clear the infection.

Niclosamide Side Effects

Common Side Effects of Niclosamide


Precautions for Taking Niclosamide

  • Inform your doctor if you have allergies to Niclosamide or any other medications.
  • Niclosamide has been studied in children aged 2 and older without causing different side effects than those in adults.
  • Its effects in elderly patients have not been fully studied.
  • Niclosamide poses a small risk to breastfeeding infants, consult your doctor.
  • Inform your doctor about all medications you are taking to prevent interactions.
  • Dosage varies by patient; follow your doctor's instructions closely.

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Dosage Information

  • Take Niclosamide as soon as you remember if you miss a dose. Skip the missed dose if your next dose is approaching. Do not double dose.

Overdose

  • Seek medical attention immediately if you suspect an overdose of Niclosamide. Symptoms may include headache, nausea, vomiting, stomach pain, diarrhea, unconsciousness, excitement, dizziness, drowsiness, seizures, difficulty breathing, and depression.

Storage

  • Store Niclosamide tablets in a cool, dry place away from direct sunlight, moisture, and heat. Keep out of reach of children. Do not keep outdated or unnecessary medications.

Niclosamide vs Fenbendazole

Niclosamide Fenbendazole
Niclosamide is an anthelmintic Fenbendazole is a broad spectrum benzimidazole anthelmintic
Formula: C13H8Cl2N2O4 Formula: C15H13N3O2S
Molecular Weight: 327.12 g/mol Molar mass: 299.349 g/mol
Brand name Niclocide Brand Names ยท Aniprazol + Praziquantel
This is a medication used to treat tapeworm infestations. Fenbendazole is a medication used to treat a variety of parasite infections.

Citations

Niclosamide: Beyond an antihelminthic drug
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Frequently Asked Questions

1. What is Niclosamide used for?

Niclosamide is used to treat tapeworm infections such as large or fish tapeworm, dwarf tapeworm, and beef tapeworm. Niclosamide can also be used to treat other tapeworm infections if your doctor recommends it. It is ineffective against other forms of worm infections (for example, pinworms or roundworms).

2. How does Niclosamide work?

Niclosamide kills tapeworms when they come into contact with it. Adult worms (but not ova) die quickly, probably as a result of oxidative phosphorylation uncoupling or ATPase activity stimulation. The worms that have been killed are either transferred in the stool or destroyed in the intestine.

3. How do you take Niclosamide?

Niclosamide can be taken without food (either 1 hour before or 2 hours after a meal). However, it is better taken after a light meal to avoid stomach discomfort (for example, breakfast). Niclosamide tablets should be chewed or crushed thoroughly before being swallowed whole with a small amount of water.

4. What does Niclosamide treat?

Niclosamide is an antihelminthic drug that is used to treat tapeworm infections. Helminths (worms) are multicellular organisms that infect large groups of people and cause a variety of illnesses.

5. What are the side effects of Niclosamide?

Common side effects of Niclosamide include

  • Abdominal pain
  • Stomach cramps or pain
  • Diarrhea
  • Loss of appetite
  • Nausea
  • Vomiting
  • Headache
  • Dizziness
  • Lightheadedness

6. Is Niclosamide safe?

Niclosamide was approved by the US Food and Drug Administration in 1982 for use in humans to treat tapeworm infection, and it is on the WHO's list of essential medicines. It has been used to treat millions of patients in a healthy manner.

7. Which parasite is susceptible to Niclosamide?

Niclosamide kills tapeworms when they come into contact with it. Adult worms (but not ova) die quickly, probably as a result of oxidative phosphorylation uncoupling or ATPase activity stimulation.

8. Does niclosamide cause constipation?

Nausea, vomiting, stomach pain, constipation, and itchiness are some of the side effects. Dizziness, skin rash, drowsiness, perianal itching, and an unpleasant taste are rare side effects. Praziquantel is a preferable and equally safe remedy for tapeworm infestation for some of these reasons.

9. Can niclosamide be taken during pregnancy?

Niclosamide is classified as a pregnancy category B drug. There is a scarcity of information on the use of niclosamide in pregnant women. Niclosamide is not believed to be consumed systemically. Only if the possible advantage outweighs the danger to the fetus can niclosamide be used during pregnancy.


Disclaimer: The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.

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