What is Olanzapine?

Olanzapine is a prescription medicine. It's available as a tablet and as a disintegrating tablet. (On your lips, the disintegrating tablet will dissolve.) Both forms are ingested orally.

There is also an injectable version available. Zyprexa (oral tablet) and Zyprexa Zydis (disintegrating tablet) are two brand-name medications that contain olanzapine. They can also be bought as generic medications. Olanzapine can be used as part of a multi-drug treatment plan. This means you would need to mix it with other drugs like -

  • Lithium,
  • Valproate or
  • Fluoxetine

Olanzapine Uses

Olanzapine is a drug that is used to treat a number of psychiatric and mood disorders (such as schizophrenia, bipolar disorder). It may also be used to treat depression in conjunction with other drugs. This drug will help you think more clearly and positively about yourself, feel less agitated, and engage more effectively in daily life by reducing hallucinations. Olanzapine belongs to the atypical antipsychotic drug class. It functions by assisting in the restoration of the brain's normal chemical equilibrium.

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Side Effects of Olanzapine

Some of the common side effects of Olanzapine are:

  • Dizziness
  • Restlessness
  • Unusual behaviour
  • Depression
  • Difficulty in falling asleep
  • Weakness
  • Difficulty walking
  • Constipation
  • Weight gain
  • Dry mouth
  • Pain in arms, legs and joints, Breast enlargement
  • Late in menstrual periods

Some of the severe side effects of olanzapine are:

  • Seizures
  • Blurred vision
  • Swelling of arms
  • Unusual movements
  • Sore throat
  • Very stiff muscles
  • Excess sweating
  • Fast or irregular heartbeat
  • Rash
  • Hives

Olanzapine can cause some other major adverse effects. When you take olanzapine, the amount of fat in your blood can rise. Teenagers taking olanzapine are more likely than adults to gain weight, have higher fat levels in their blood, develop liver problems, and experience side effects including sleepiness and breast enlargement. Consult your doctor about the dangers of olanzapine use.


Precautions of Olanzapine

Before taking olanzapine, talk with your doctor if you are allergic to it or any other medications. The product may contain some inactive ingredients, which can cause serious side effects and some serious allergic reactions. Before using Olanzapine, talk with your doctor if you have any medical history, such as:

  • Liver problems
  • Seizures
  • Difficulty swallowing
  • Dementia
  • Glaucoma
  • Intestinal problems
  • Heart disease
  • High cholesterol

How to take Olanzapine?

  • Olanzapine is available as a tablet and an orally disintegrating tablet.
  • Take olanzapine once a day, with or without food, at the same time each day.
  • Follow your doctor's dosage instructions exactly.
  • Do not push the orally disintegrating tablet through the foil; peel back the foil with dry hands.
  • Place the tablet in your mouth immediately; it will dissolve easily and can be taken with or without water.
  • Olanzapine manages symptoms but does not cure the disease.
  • Full benefits may take weeks or months to appear.
  • Continue taking olanzapine even if you feel well.
  • Do not stop olanzapine abruptly; consult your doctor to gradually reduce the dosage.

Dosage 

Forms and strengths

Generic: Olanzapine

  • Form: oral tablet (2.5 mg, 5 mg, 7.5 mg, 10 mg, 15 mg, 20 mg)
  • Form: oral disintegrating tablet (5 mg, 10 mg, 15 mg, 20 mg)

Brand: Zyprexa

  • Form: oral tablet (2.5 mg, 5 mg, 7.5 mg, 10 mg, 15 mg, 20 mg)

Brand: Zyprexa Zydis

  • Form: oral disintegrating tablet (5 mg, 10 mg, 15 mg, 20 mg)

Missed Dose of Olanzapine

If you forget to take a dose, do so as soon as you recall. If the next dose is coming, skip the skipped dose. Take the next dose at the same time every day. To catch up, do not double the dose.

Overdose of Olanzapine

An overdose of a drug can be accidental. If you have taken more than the prescribed olanzapine tablets, there is a chance of a harmful effect on your body’s functions. An overdose of a medicine can lead to a medical emergency.


Warnings for some serious health conditions

For people with Alzheimer’s disease

Olanzapine isn't licensed to treat Alzheimer's disease or dementia-related psychosis. Olanzapine increases the risk of death in seniors with dementia-related psychosis (age 65 or older). Heart complications, such as heart failure, and infectious diseases, such as pneumonia, account for the bulk of these deaths.

For people with diabetes or high sugar levels

Olanzapine can cause blood sugar to rise. Before and during treatment with this drug, your doctor can monitor your blood sugar levels. Any diabetes drugs you're taking may need to be changed.

For people with heart problems

Olanzapine can cause a drop in blood pressure that is unexpected. If you have a history of heart attacks, contact your doctor and see if this medicine is right for you. Heart disease, a history of heart attack or stroke, heart failure, or problems with blood flow through the heart are all examples of these concerns. They also include any problems that may deteriorate if the blood pressure falls too low.

For people with Blood problems

Low levels of white blood cells, or neutrophils, may be caused by olanzapine. Infections are more common at these low levels. If you have a history of blood disorders or are taking other medications that can reduce these blood cell levels, your doctor should check your blood regularly during the first few months of treatment with this medicine. They can also keep an eye on you for any signs of illness, such as a fever.

Pregnancy

If the benefits outweigh the risks, use olanzapine with caution during pregnancy. Animal studies indicate a possibility, but human studies are either unavailable or have not been performed. Extrapyramidal symptoms (EPS) or withdrawal symptoms in neonates exposed to antipsychotic medications during the third trimester of pregnancy are a concern after delivery; the severity of these complications varies, and some are self-limited.

Breastfeeding

Olanzapine can pass into breast milk and cause side effects in a breastfed infant. If you're taking olanzapine, you shouldn't breastfeed. If you are breastfeeding your infant, talk with your doctor. You must choose whether or not to avoid breastfeeding or take this drug.


Storage

Direct contact with heat, air and light may damage your medicines. Exposure to medicine may have some harmful effects. The medicine must be kept in a safe place and out of children’s reach. Mainly, the drug should be kept at room temperature between 68 °F and 77 °F (20 °C and 25 °C).

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Olanzapine vs Risperidone

Olanzapine Risperidone
Olanzapine belongs to the atypical antipsychotic drug class. It functions by assisting in the restoration of the brain's normal chemical equilibrium. Risperidone belongs to the atypical antipsychotic drug class. It functions by assisting in the restoration of the brain's normal chemical equilibrium.
Olanzapine is a drug that is used to treat a number of psychiatric and mood disorders Risperidone is a drug that is used to treat a number of psychiatric and mood conditions. This drug will assist you in thinking logically and engaging in daily activities.
Some of the common side effects of Olanzapine are:
  • Dizziness
  • Restlessness
  • Unusual behaviour
  • Depression
  • Difficulty in falling asleep
Most common side effects of Risperidone are:
  • Dizziness
  • Anxiety
  • Blurred vision
  • Dry mouth
  • Abdominal pain
  • Increased appetite

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Frequently Asked Questions

1. What is the side effect of olanzapine?

Some of the common side effects of Olanzapine are:

  • Dizziness
  • Restlessness
  • Unusual behaviour
  • Depression
  • Difficulty in falling asleep

2. Is olanzapine used for anxiety?

Typical antipsychotics, including quetiapine, aripiprazole, olanzapine, and risperidone, have been shown to benefit people with schizophrenia and schizoaffective disorders with a variety of anxiety and depressive symptoms.

3. Will olanzapine calm me down?

It relaxes the mind, relieves intense anxiety, and helps me sleep at night. This drug has had no negative side effects for me. It is really a lifesaver. If you really need this drug, don't be afraid to start taking it.

4. What should I avoid while taking olanzapine?

While taking olanzapine, it's important to avoid consuming alcohol, as it can increase the risk of side effects such as drowsiness and dizziness. Additionally, you should avoid activities that require mental alertness, such as driving or operating heavy machinery, until you know how olanzapine affects you. Also, be cautious with overheating or dehydration, as olanzapine can impair the body's ability to regulate temperature.

5. What do I need to know before taking olanzapine?

Before taking olanzapine, inform your healthcare provider about any medical conditions you have, especially if you have a history of diabetes, liver problems, seizures, or a low white blood cell count. Let them know about any medications, vitamins, or supplements you are currently taking, as they may interact with olanzapine. It's important to follow your healthcare provider's instructions closely, including the dosage and duration of treatment.

6. How does the drug Olanzapine work?

The drug olanzapine works by affecting the actions of certain chemicals in the brain, particularly serotonin and dopamine. This action helps to alleviate symptoms of schizophrenia and bipolar disorder, such as hallucinations, delusions, and mood swings.

7. What is the difference between Olanzapine and Olanza?

Olanzapine is the generic name of the medication, while Olanza is a brand name for the same drug. Both contain the same active ingredient and are used for treating similar conditions like schizophrenia and bipolar disorder.

8. What is Oleanz 5 used for?

Oleanz 5 is a brand name for olanzapine and is used to treat schizophrenia and bipolar disorder. The 5 mg dosage is commonly prescribed for patients who need a moderate dose to manage their symptoms effectively.

9. Can Olanzapine 5mg be used for anxiety?

Olanzapine 5mg is not typically prescribed for anxiety alone. However, it may be used in combination with other medications to manage anxiety symptoms in patients with schizophrenia or bipolar disorder.


Disclaimer: The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.

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