What is Perphenazine?

Perphenazine belongs to a class of medications known as phenothiazines, specifically used as an antipsychotic drug. It is primarily prescribed to manage schizophrenia and other related psychiatric conditions. Additionally, it can help alleviate severe nausea and vomiting.

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Uses of Perphenazine:

Perphenazine is utilized for the treatment of various mental and mood disorders, including:

  • Schizophrenia: Helps in reducing symptoms such as hallucinations, delusions, and disorganized thinking.
  • Bipolar Disorder: Particularly during the manic phase, to stabilize mood and behavior.
  • Schizoaffective Disorder: A condition that involves symptoms of both schizophrenia and mood disorders.

How Perphenazine Works:

Perphenazine acts by restoring the balance of certain natural substances in the brain, notably dopamine. Dopamine imbalance is associated with symptoms of schizophrenia and other psychotic disorders.


Dosage and Administration:

  • Dosage: Typically prescribed 1 to 3 times daily, as directed by a healthcare provider. Initial doses are often low and gradually increased to minimize potential side effects such as muscle spasms .
  • Administration: Perphenazine can be taken with or without food, depending on individual tolerance.

Side Effects of Perphenazine:

Common side effects may include:

  • Pale skin
  • Dry mouth
  • Excess saliva
  • Stuffy nose
  • Headache
  • Nausea and vomiting
  • Diarrhea
  • Constipation
  • Loss of appetite
  • Blank facial expression
  • Shuffling walk

Serious side effects that require immediate medical attention include:

  • Fever
  • Muscle stiffness
  • Falling
  • Confusion
  • Fast or irregular heartbeat
  • Sweating
  • Decreased thirst
  • Neck cramps
  • Skin rash or itching
  • Hives

Precautions:

Before taking Perphenazine, inform your doctor about any allergies, current medications, and medical conditions, especially:

  • Liver problems
  • Low blood pressure
  • Breathing difficulties
  • History of decreased bone marrow function
  • Recent serious head injury
  • Breast cancer
  • Irregular heartbeat

Interactions:

Perphenazine may interact with several medications, including those used for Parkinson's disease (e.g., levodopa), certain anticholinergic drugs, and medications that affect liver enzymes (e.g., fluoxetine). Always inform your healthcare provider about all medications you are taking to prevent potential interactions.

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Storage:

Store Perphenazine at room temperature, away from heat, light, and moisture. Keep it out of reach of children.

Perphenazine is an effective antipsychotic medication used to manage schizophrenia and related psychiatric conditions. It helps patients think more clearly, reduce aggression, and improve daily functioning. It is crucial to follow your doctor's instructions regarding dosage and report any unusual symptoms or side effects promptly.

If you have any concerns or experience adverse effects while taking Perphenazine, consult your healthcare provider for guidance and appropriate management.

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Frequently Asked Questions

1. What is the brand name for perphenazine?

Perphenazine is branded under names such as Trilafon, Etrafon (or Triavil/Triptafen when combined with amitriptyline), and Decentan in Europe.

2. Does perphenazine help with anxiety?

Perphenazine has a broad spectrum of efficacy and can be effective in treating various levels of anxiety and agitation, from moderate stress or hyperactivity to severe psychosis or psychomotor agitation.

3. When should I take perphenazine?

Perphenazine should be taken orally, usually with or without food, as prescribed by your doctor. Typically, it is taken 1-3 times daily, depending on your medical condition and response to therapy.

4. Does perphenazine make you sleepy?

Common side effects of perphenazine include drowsiness, constipation, dry mouth, dizziness, blurred vision, fatigue, and unexplained weight gain.

5. What are the side effects of taking perphenazine?

Common side effects of perphenazine may include pale skin, dry mouth, excessive saliva production, stuffy nose, headache, and nausea. If you experience severe side effects, contact your doctor.


Disclaimer: The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.

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