What is Prostin?

Prostin, also known as Dinoprostone, is a prostaglandin E2 (PGE2) that occurs naturally in the body. It is used medically to induce labor, aid in cervical ripening, and manage certain pregnancy-related conditions.

Prostin Uses:

Labor Induction: Used to prepare the cervix for labor induction near term (end of pregnancy).
Abortion: Can be used to induce abortion between 12 to 20 weeks of pregnancy, or to manage incomplete abortion or miscarriage up to 28 weeks of pregnancy.
Other Uses: Also used for treating benign hydatidiform mole, a specific type of uterine condition.

Prostin Side Effects:

Common Side Effects: Fever, irregular heartbeats, nausea, stomach pain, and back pain.
Serious Side Effects: Light-headed feeling, weak or shallow breathing, vaginal bleeding, unexpected stomach pain, chest pain, easy bruising, and bleeding from wounds.

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Precautions:

Allergies: Inform your doctor of any allergies to Prostin or related medications.
Medical History: Discuss any history of anemia, asthma, low blood pressure, diabetes, glaucoma, heart disease, kidney disease, liver disease, infections in the vaginal area, or seizure disorder.

How to Take Prostin:

Administration: Inserted vaginally as a suppository by a healthcare provider.
Positioning: Remain reclined or lying down for at least 10 minutes after insertion.
Dosage: Additional doses may be given every 3-5 hours until the desired effect (contractions or abortion) is achieved, typically not exceeding 48 hours.
Hospital Setting: It should only be used in a hospital under medical supervision due to the need for monitoring and potential complications.

Storage:

Store at room temperature (68ºF to 77ºF), away from heat, light, and moisture. Keep out of reach of children.

Prostin vs Cytotec (Misoprostol):

Prostin (Dinoprostone): Naturally occurring prostaglandin used for labor induction and managing specific uterine conditions.
Cytotec (Misoprostol): Used primarily to prevent stomach ulcers when taking nonsteroidal anti-inflammatory drugs (NSAIDs) and for inducing abortion or managing postpartum hemorrhage.

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Side Effects Comparison:

Prostin: Fever, irregular heartbeats, nausea, stomach pain, back pain.
Cytotec: Diarrhea, stomach pain, nausea, vaginal bleeding.

Citations

The Use of 15 Methyl F2αProstaglandin (Prostin 15M) for the Control of Postpartum Hemorrhage
Induction of labour at term with vaginal prostaglandins preparations: A randomised controlled trial of Prostin vs Propess

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Frequently Asked Questions

1. How long does prostin take to work?

If no contractions have occurred after 6 hours, you will be given another tablet or gel. It can take up to 24 hours for a controlled-release pessary inserted into your vagina to start working. You could be given another dose if you do not have contractions after 24 hours.

2. How is prostin gel inserted?

This gel is injected into the cervix by a syringe inserted into the vaginal canal. The medication aids in the dilation of the cervix, allowing the birth canal to develop. The contractions should start slowly, and you will be able to return home after the gel has been applied for a few hours.

3. Does prostin cause contractions?

Prostaglandins are used to induce labor and are generally safe. Some women may experience intense contractions known as "prostin" contractions, which can lead to discomfort. In some cases, prolonged contractions may affect the baby's heart rate.

4. What are the side effects of prostin?

Some of the side effects of Prostin include fever, irregular heartbeats, nausea, stomach pain, and back pain.

5. What is the use of Prostin?

Prostin is a prostaglandin, a natural substance produced by the body in preparation for labor. It softens and widens the opening of the womb while promoting contractions.

Disclaimer: The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.