What is Raloxifene?
Raloxifene is a prescription medication used primarily by postmenopausal women to prevent and treat osteoporosis (bone loss). It helps maintain bone density and reduces the likelihood of fractures. Additionally, Raloxifene can decrease the risk of invasive breast cancer in postmenopausal women. It is a selective estrogen receptor modulator (SERM) that mimics the effects of estrogen on bones while blocking estrogen's effects on other tissues, such as the breast and uterus. However, it does not alleviate menopausal symptoms like hot flashes.
Uses of Raloxifene
Raloxifene is used for:
- Preventing and treating osteoporosis in postmenopausal women.
- Reducing the risk of invasive breast cancer in postmenopausal women with osteoporosis or at high risk for breast cancer.
Side Effects of Raloxifene
Common side effects include:
- Hot flashes
- Leg cramps
- Swelling of hands and feet
- Joint pain
- Sweating
- Diarrhea
- Nausea
- Weight gain
- Muscle pain
Serious side effects may include:
- Insomnia
- Sweating
- Breast pain
- Bronchitis
- Pharyngitis
- Increased triglycerides
- Deep vein thrombosis
- Stroke
If you experience serious side effects, contact your doctor immediately.
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Before taking Raloxifene, inform your doctor if you:
- Are allergic to Raloxifene or any of its components.
- Have a history of liver disease, kidney disease, abdominal pain, heart disease, or stomach cramps.
How to Use Raloxifene
- Take the medication once daily, with or without food.
- If undergoing major surgery or long-term bed rest, stop taking the drug at least 3 days before the procedure and resume once you are mobile.
- The usual dosage is 60 mg per day.
How Raloxifene Works
Raloxifene acts as an estrogen receptor modulator:
- In bones: Mimics estrogen to maintain bone density and prevent fractures.
- In breast tissue: Blocks estrogen's effects, reducing the risk of hormone-driven breast cancer.
Missed Dose
- If you miss a dose, take it as soon as you remember.
- If it is almost time for your next dose, skip the missed dose and continue with your regular schedule.
- Do not double the dose to catch up.
Overdose
In case of overdose, seek immediate medical attention. Symptoms may include nausea, vomiting, headache, and hot flashes.
Drug Interactions
Raloxifene can interact with various medications, including:
- Ospemifene
- Cholestyramine
- Famciclovir
- Levothyroxine
- Warfarin
Always inform your doctor about all the medications you are taking to avoid potential interactions.
Warnings for Serious Health Conditions
- Raloxifene can cause deep vein thrombosis and pulmonary embolism.
- Women with a history of thromboembolism should avoid this medication.
- It may increase the risk of stroke in postmenopausal women with coronary heart disease or risk factors for coronary events.
- Pregnant women should avoid this medication due to potential adverse effects on the unborn child.
- Raloxifene can pass into breast milk and may harm the nursing infant.
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- Store at room temperature (68°F to 77°F or 20°C to 25°C).
- Keep away from direct heat, light, and moisture.
- Store in a safe place, out of the reach of children.
Raloxifene vs. Femara
| Raloxifene | Femara |
|---|---|
| Used to prevent and treat osteoporosis in postmenopausal women. | Used to treat cancer in postmenopausal women. |
| Belongs to selective estrogen receptor modulators (SERMs). | Stimulates ovulation in women with PCOS and infertility. |
| Common side effects: joint pain, swelling, leg cramps, hot flashes. | Common side effects: fatigue, hypercholesterolemia, hot flashes, increased sweating. |
Consult your healthcare provider for personalized advice and recommendations based on your specific medical condition and treatment needs.
