What is Ramelteon?

  • Ramelteon, marketed under the brand name Rozerem, is a sleep agent medicine.
  • It binds exclusively to the suprachiasmatic nucleus of the MT1 and MT2 receptors, unlike drugs such as zolpidem, which bind to GABAA receptors.

Ramelteon Uses

  • Helps patients fall asleep more rapidly who have sleep-onset insomnia (difficulty falling asleep).
  • Belongs to a class of medicines called agonists of the melatonin receptor.
  • Functions similarly to melatonin, a natural substance in the brain required for sleep.

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Ramelteon Side Effects:

Common Side Effects:

  • Swelling of the tongue or throat
  • Difficulty swallowing or breathing
  • Feeling that the throat is closing
  • Nausea
  • Vomiting
  • Irregular or missed menstrual periods

Serious Side Effects:

  • Milky discharge from the nipples
  • Decreased sexual desire
  • Fertility problems
  • Drowsiness or tiredness
  • Dizziness

Precautions Required To Be Taken For Ramelteon

  • Notify your doctor if you are allergic to Ramelteon or any other drugs.
  • Inform your doctor if you are taking fluvoxamine (Luvox).
  • Tell your doctor about any history of suicidal thoughts or attempts, chronic obstructive pulmonary disease ( COPD), or other lung diseases, and sleep apnea.
  • Inform your doctor if you are pregnant, planning to become pregnant or breastfeeding.
  • Do not drink alcohol during treatment as it can worsen side effects.
  • Be cautious of endocrine effects, including reduced testosterone and increased prolactin levels.
  • Use caution in patients with respiratory disability, including sleep apnea or COPD, not recommended for patients with severe sleep apnea.
  • Use caution in patients with hepatic impairment, not recommended for severe hepatic impairment.
  • Be aware of potential drug interactions.

How to Take Ramelteon

  • Comes as a tablet to take by mouth.
  • Take once a day, 30 minutes before bedtime.
  • Do not take with you a meal or soon after.
  • Follow prescription instructions carefully.
  • Swallow whole tablets; do not divide, chew, or crush them.
  • Finish bedtime preparations and go to bed after taking Ramelteon.
  • Do not use it if you cannot stay asleep for 7 to 8 hours after taking it.
  • Insomnia should improve within 7 to 10 days; consult your doctor if it does not.
  • Read the Medication Guide provided by your doctor or pharmacist.

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How Does Ramelteon Work?

  • High affinity for melatonin MT1 and MT2 receptors, low selectivity for the MT3 receptor.
  • Melatonin levels rise with nocturnal sleep, associated with sleepiness and increased sleep tendency.
  • MT1 receptors control sleepiness and promote sleep onset.
  • MT2 receptors mediate melatonin's phase-shifting effects on circadian rhythm.
  • No significant affinity for other neuropeptides, cytokines, serotonin, dopamine, norepinephrine, acetylcholine or opiates.

Ramelteon Dosage Information

  • Adult Dose: 8 mg taken within 30 minutes of bedtime.
  • Do not take with or directly after a high-fat meal.
  • Do not exceed 8 mg daily.

Dosing in Patients with Hepatic Deficiency:

  • Not recommended for patients with serious liver disease.
  • Use with caution in patients with mild liver disease.

Management of Other Drugs:

  • Do not use fluvoxamine.
  • Use with caution in patients taking other CYP1A2 inhibiting medications.

Storage:

  • Store away from heat, air, and light.
  • Keep out of reach of children.

Ramelteon vs Melatonin:

Ramelteon Melatonin
Formula: C16H21NO2 Formula: C13H16N2O2
Is a sleep agent medication Associated with control of the sleep-wake cycle.
Ramelteon is used to help patients fall asleep more rapidly who have sleep-onset insomnia Used for the short-term treatment of insomnia
Brand Name: Rozerem Brand Name: N-acetyl-5-methoxytryptamine

Citations

Ramelteon
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Frequently Asked Questions

1. Is Ramelteon the same as melatonin?

Ramelteon (Rozerem) is a type 1 and type 2 agonist of the highly selective melatonin receptor 1,2, unlike non-prescription melatonin, which is not selective for all three melatonin receptors.

2. Is Ramelteon a narcotic?

It acts by stimulating the brain's receptors for melatonin. Melatonin and its receptors regulate the body's circadian rhythm, which regulates the sleep/wake cycle. Ramelteon is not addictive, and it is not a controlled substance, unlike many drugs used for treating insomnia.

3. What are the side effects of Ramelteon?

Some common side effects are swelling of the tongue, difficulty in swallowing or breathing, feeling discomfort in the throat, Nausea, Vomiting, irregular or missed menstrual periods, milky discharge from the nipples, decreased sexual desire, fertility problems, drowsiness or tiredness, dizziness.

4. Does Ramelteon cause weight gain?

It may or may not cause you to weight gain, depends on your body.

5. What is the best sleeping pill for the elderly?

In the elderly, nonbenzodiazepines are safer and better tolerated than tricyclic antidepressants, antihistamines, and benzodiazepines, such as zolpidem, eszopiclone, zaleplon, and ramelteon. Only after sleep hygiene is discussed, however, should pharmacotherapy be recommended.

6. Can you take Ramelteon and melatonin together?

Even though GABA is not mediated by melatonin agonists, it is suggested that melatonin and ramelteon should not be mixed with alcohol. Alcohol may decrease the sleep effectiveness of melatonin and, when combined with ramelteon, may have additive CNS effects and increase the risk of sleep-related complex behaviors.


Disclaimer: The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.

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