What is Rasagiline?

Rasagiline is an irreversible monoamine oxidase-B (MAO-B) inhibitor used primarily to treat symptoms of early Parkinson's disease. It can be used alone or in combination with other medications like levodopa/carbidopa. By inhibiting MAO-B, rasagiline helps increase the levels of dopamine, norepinephrine, and serotonin in the brain, which are neurotransmitters involved in regulating movement and mood.

Rasagiline Uses:

Parkinson's Disease : It is prescribed to alleviate symptoms such as tremors, stiffness, and difficulty with movement associated with Parkinson's disease. It can also reduce "off" times, periods when Parkinson's symptoms worsen despite treatment.
Mechanism of Action : Rasagiline's inhibition of MAO-B helps maintain higher levels of dopamine in the brain, which is crucial for motor function.

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How to Use Rasagiline:

Take rasagiline orally, once daily, with or without food, as directed by your doctor. It's important not to exceed the prescribed dosage or frequency.
Avoid suddenly stopping the medication without consulting your doctor, as this can worsen certain conditions.
Tyramine-rich foods (like aged cheeses) should be avoided while taking rasagiline to prevent a potentially dangerous increase in blood pressure. Consult your doctor or a dietician for specific dietary recommendations.
If you miss a dose, take it as soon as you remember. However, if it's near the time for your next dose, skip the missed dose and continue with your regular schedule.

Rasagiline Side Effects:

Common side effects may include depressed mood, sleep problems, involuntary muscle movements, loss of appetite, indigestion, stomach pain, nausea, vomiting, constipation, joint pain, rash, cough, flu symptoms, dry mouth, and swelling of hands or feet.

Precautions:

Inform your doctor about any allergies and medical history, especially of liver disease, glaucoma, breathing problems, heart disease, kidney disease, stomach/intestinal ulcers, mood disorders, or blood disorders.
Rasagiline may cause dizziness or drowsiness. Avoid alcohol consumption, which can exacerbate these effects.
Use during pregnancy is only recommended if clearly needed, as its effects on the fetus are not well understood. Consult your doctor before breastfeeding while taking rasagiline.
Be cautious of drug interactions, especially with medications that increase serotonin levels or other MAO inhibitors.

Interactions:

Inform your doctor about all medications you are taking, including prescription, over-the-counter, and herbal products, to avoid interactions that could affect the safety and efficacy of rasagiline.

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Storage:

Store rasagiline away from heat, light, and moisture at room temperature. Keep it out of reach of children.

Rasagiline vs Selegiline:

Rasagiline : An irreversible MAO-B inhibitor used to treat early Parkinson's disease symptoms by increasing dopamine, norepinephrine, and serotonin levels.
Selegiline : Also an MAO-B inhibitor used for Parkinson's disease treatment, it works by preventing dopamine breakdown, thereby increasing its activity. Selegiline is also used in the treatment of major depressive disorder.

Citations

Rasagiline A controlled, randomized, delayed-start study of rasagiline in early Parkinson disease

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Frequently Asked Questions

1. What is rasagiline used for?

Rasagiline is used to treat symptoms of Parkinson's disease, such as stiffness, tremors, spasms, and poor muscle control. It may be used alone or in combination with other medications like levodopa.

2. Does rasagiline slow Parkinson's disease progression?

No, rasagiline is not effective at slowing the progression of Parkinson's disease according to FDA reviews. Its primary benefit is in managing the symptoms of the disease.

3. How does rasagiline work for Parkinson's disease?

Rasagiline works by inhibiting the breakdown of dopamine in the brain, which helps alleviate motor symptoms of Parkinson's disease.

4. When is the best time to take rasagiline?

Take rasagiline tablets exactly as directed by your doctor, usually once daily. It can be taken with or without food, but it's advisable to take it at the same time each day.

5. Does rasagiline cause insomnia?

Insomnia is a possible side effect of rasagiline. Other common side effects include peripheral edema, falls, arthralgia, and cough.

6. How does rasagiline work in the brain?

Rasagiline increases the levels of dopamine, norepinephrine, and serotonin in the brain, which helps improve symptoms of Parkinson's disease.

7. Can rasagiline cause constipation?

Yes, constipation is a known side effect of rasagiline.

8. Does rasagiline interact with fluoxetine?

Rasagiline should not be taken with other MAO inhibitors, including fluoxetine, due to the risk of serious and potentially fatal drug interactions. Always consult your doctor before starting or stopping any medications.

Disclaimer: The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.