What is Savella?

Savella is a prescription medicine used to treat fibromyalgia. It is the first-choice medication for this condition. You can take these tablets with or without food but must follow a strict schedule, which can be perplexing in the first month.

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Savella Uses

Savella treats pain caused by fibromyalgia, which affects muscles, tendons, ligaments, and tissue support. This medicine is a Serotonin-Norepinephrine Reuptake Inhibitor (SNRI) that helps restore the balance of certain natural substances in the brain (neurotransmitters).

Instructions:

    • Read your pharmacist’s medication guide before using Milnacipran whenever you get a refill.
    • Consult your doctor.
    • Take this medicine orally with or without food, usually twice a day or as directed by your doctor. If you have nausea, it may help to take this medicine with your food.
    • The dosage is based on your health condition, medical history, and response to treatment.
    • Your doctor may prescribe a low dose to reduce your risk of side effects and gradually increase the dose.
    • Do not suddenly stop using this medicine to avoid withdrawal symptoms. Your doctor may lower your dosages slowly.

Savella (Milnacipran) Side Effects

Common side effects include:

  • Nausea
  • Headache
  • Constipation
  • Drowsiness
  • Tiredness
  • Weakness
  • Dizziness
  • Trouble sleeping
  • Hot flush
  • Increased sweating
  • Vomiting
  • Irregular heartbeat (palpitations)
  • Increased heart rate
  • Dry mouth
  • High blood pressure
  • Hypertension
  • Irritation
  • Rashes
  • Vomit
  • Lightheadedness

Precautions

Before using Savella:

  • Inform your doctor if you are allergic to Savella (Milnacipran) or Levomilnacipran or have any other allergies.
  • This product may contain inactive ingredients that can cause allergic reactions or other problems.
  • Discuss your medical history with your doctor or pharmacist, including kidney disease, liver disease, personal or family history of glaucoma, psychiatric disorders, suicide attempts, high blood pressure, and heart problems.
  • Older adults may be at higher risk of mineral imbalance (low sodium levels in the blood), especially if taking diuretics.
  • Consult your doctor before breastfeeding as this medicine passes into breast milk.

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Interactions with Other Medications

  • Using Savella with other drugs can increase drowsiness. Ask your doctor before taking opioid medication, sleeping pills, muscle relaxers, or anxiety/seizure medications.
  • Inform your doctor about all your current medicines, including prescription and over-the-counter medicines, vitamins, and herbal products.

Dosage of Savella

  • The dosage depends on your age, health condition, other medications used, and other factors. Follow your doctor's prescription.

Overdose

If you overdose, contact your doctor immediately to avoid any emergency. Symptoms of an overdose may include dizziness, drowsiness, headache, and vomiting.


Missed Dose

If you miss a dose, take it as soon as you remember. If it’s almost time for the next dose, skip the missed dose and take the next one.


Storage of Savella Tablets

  • Store at room temperature away from light, heat, and moisture.
  • Keep out of reach of children.

Savella vs. Cymbalta

Savella Cymbalta
Treats fibromyalgia. Improves mood and relieves certain types of pain.
Used for pain caused by fibromyalgia affecting muscles, tendons, ligaments, and tissue support. Used for treating depression, anxiety, diabetic neuropathy, fibromyalgia, chronic muscle pain, urinary incontinence (women).
Available only as a brand name; high copay. Available as a generic.

Citations

Original Research ReportGestational Weight Gain and Pre-pregnancy Body Mass Index Associated With Second-Generation Antipsychotic Drug Use During Pregnancy
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Frequently Asked Questions

1. Does Savella make you lose weight?

Savella has not been linked to either weight gain or weight loss in clinical trials. In clinical trials, patients who took Savella lost an average of 1.76 pounds compared to patients who took a placebo who lost an average of 0.44 pounds.

2. Is Savella a narcotic?

Stopping Savella too soon, as with other drugs in its class (SNRIs and SSRIs), can cause withdrawal symptoms. Rather than stopping immediately, the healthcare provider will work with you to gradually reduce your dosage. Savella is a non-narcotic pain reliever that does not induce addiction.

3. What is Savella used for?

Milnacipran (Savella) can help people with fibromyalgia feel less tired. Fibromyalgia is a chronic condition characterized by widespread pain that lasts for at least three months.

4. Does Savella help with depression?

Savella is a potent serotonin and norepinephrine reuptake inhibitor (SNRI), which is close to some antidepressants and other psychiatric medications.

5. Does Savella work immediately?

Savella isn’t a pain reliever, and it doesn’t work right away. It’s important to remember to take Savella early and with food. Take it twice a day, at 5 a.m. and 2 a.m. (for seven weeks). It can cause headaches and nausea if not taken properly.

6. What are the more common side effects of Savella?

Common side effects include nausea, headache, constipation, drowsiness, tiredness, weakness, and dizziness.

7. Is Savella an antidepressant?

Savella is an antidepressant that belongs to the Serotonin and Norepinephrine Reuptake Inhibitors class of medicines (SNRI).

8. How long does it take for Savella to start working?

Savella takes about 10 to 14 days to start working.

9. Does Savella cause anxiety?

If you suddenly stop taking Savella, you can experience withdrawal symptoms such as dizziness, anxiety, irritability, fatigue, headache, ringing in your ears, and sleep issues.

10. Does Savella make you sleepy?

If you take Savella with food, you may find it more tolerable. Common side effects include headache, constipation, dizziness, insomnia, hot flush, hyperhidrosis (excessive sweating), vomiting, palpitations, elevated heart rate, dry mouth, and hypertension.


Disclaimer: The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.

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