Sotalol, known by the brand name Betapace, is a medication used primarily to treat and prevent abnormal heart rhythms (arrhythmias). It belongs to a class of drugs called beta-blockers and is also classified as an antiarrhythmic agent.
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The most common side effects of sotalol are dizziness or sickness, fatigue, diarrhea, or headache – all of which are usually mild and temporary. If you're taking a very high dose, you're more likely to experience side effects. Because your first dose may cause dizziness, take it before going to bed.
Sotalol is a unique beta-blocker with antiarrhythmic effects in classes II and III. As a nonselective beta-blocker, it lacks intrinsic sympathomimetic and membrane-stabilizing activity. Like amiodarone, it prolongs the action potential duration (APD) and increases refractoriness.
Sotalol belongs to the class of antiarrhythmic medications used to treat irregular heartbeats.
Sotalol is considered safe for use in patients with a damaged heart, such as those who have had a heart attack.
Sotalol is a safe and effective agent for controlling heart rates in patients with atrial fibrillation and is considered better than metoprolol for rate control during daily activities.
Sotalol may cause increased serum levels in patients with impaired kidney function due to its pharmacokinetic properties.
Sotalol's bioavailability is reduced when taken with food or milk. Therefore, it should be taken on an empty stomach, ideally 1-2 hours before or after meals or milk-containing products.
Side effects of sotalol 80 mg may include difficulty breathing, dizziness, fatigue, slow heart rate, chest pain, irregular heartbeat, weakness, and lightheadedness.
If the 80 mg dose level, given twice daily or once daily depending on creatinine clearance (CrCl), does not reduce the frequency of atrial fibrillation/atrial flutter relapses and is tolerated without excessive QT interval prolongation, it may be adjusted.
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