What is Tiagabine ?

Tiagabine is a medication used in conjunction with other medications to treat partial seizures (a type of epilepsy). It belongs to the class of anticonvulsant medications. Although the exact mechanism of action of Tiagabine is not fully understood, it is known to increase the number of natural chemicals in the brain that help prevent seizure activity.


Uses of Tiagabine

  • Seizure Management: Tiagabine is used to treat focal seizures, working by preventing seizure activity from spreading throughout the brain.
  • Anticonvulsant: Classified as an anticonvulsant or anti-epileptic medication.

How to Use Tiagabine HCI

  • Medication Guide: Read the Medication Guide provided by your pharmacist before starting Tiagabine and each time you get a refill.
  • Dosage: Take this medication orally with food as directed by your doctor. Start with a low dose and gradually increase it to reduce side effects. Usually taken once a day during the first week, with the dose possibly increasing to 2 to 4 times daily in the following weeks.
  • Combination Therapy: Tiagabine is rarely used on its own; do not stop taking other anti-seizure medications unless instructed by your doctor.
  • Consistency: Take it regularly at the same time each day for maximum benefit.
  • Discontinuation: Do not abruptly stop taking this medication, as it may worsen your condition. Gradually reduce the dose if necessary.
  • Restarting Medication: If you stop taking Tiagabine for an extended period, consult your doctor on how to restart it, possibly starting with a low dose again.

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Side Effects of Tiagabine

Common Side Effects:

  • Dizziness
  • Lightheadedness
  • Drowsiness
  • Lack of energy or weakness
  • Wobbliness, unsteadiness, or incoordination causing difficulty walking
  • Depression
  • Anger
  • Irritability
  • Confusion
  • Difficulty concentrating
  • Abnormal thinking
  • Speech or language problems
  • Increased appetite
  • Nausea
  • Stomach pain
  • Nervousness
  • Difficulty falling asleep or staying asleep
  • Itching
  • Bruising
  • Painful or frequent urination

Precautions

  • Allergies: Inform your doctor if you are allergic to Tiagabine or any other medications. The product may contain inactive ingredients that can cause allergic reactions or other problems.
  • Medical History: Discuss your medical history with your doctor, especially if you have liver disease, mental/mood disorders (such as depression or suicidal thoughts), or a seizure that does not stop (status epilepticus).
  • Older Adults: May be more sensitive to the side effects, particularly dizziness or confusion, which may increase the likelihood of falling.
  • Pregnancy: Use only when prescribed during pregnancy. Discuss the benefits and drawbacks with your doctor.

Interactions

  • Orlistat: May interact with this medication.
  • Drowsy Products: Inform your doctor if you are taking other drowsy products, such as alcohol, antihistamines, sleep or anxiety medications, muscle relaxants, or opioid pain relievers.
  • Medication Labels: Check labels for drowsy ingredients. Consult your pharmacist on how to use those products safely.

Overdose

  • Emergency: In case of overdose with serious symptoms such as passing out or trouble breathing, seek medical advice immediately. Never take more than the prescribed dose.

Missed Dose

  • Procedure: If you miss a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and take the next one at the regular schedule. Do not double the dose.

Storage

  • Conditions: Keep the medicine away from direct contact with heat, air, and light to avoid damage. Store in a safe place out of children’s reach.

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Tiagabine vs Gabapentin

Tiagabine Gabapentin

Tiagabine belongs to the anticonvulsant medication class.

Gabapentin is available as the brand-name drug Neurontin. It is also available as a generic drug.

Used in conjunction with other medications to treat partial seizures (a type of epilepsy).

Gabapentin oral capsule is prescribed for the treatment of partial seizures in adults and children.

Works by preventing seizure activity from spreading throughout the brain.

Also used to treat nerve pain caused by shingles.


Citations

Tiagabine
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Frequently Asked Questions

1. What is tiagabine used for?

Tiagabine is used in combination with other medications to treat partial seizures, which are a type of epilepsy. It belongs to the anticonvulsant medication class.

2. What is the indication for tiagabine?

Tiagabine hydrochloride is indicated as adjunctive therapy in the treatment of partial seizures in adults and children 12 years of age and older.

3. What are the common side effects of tiagabine?

Common side effects of tiagabine include dizziness, lightheadedness, drowsiness, lack of energy or weakness, wobbliness or incoordination causing difficulty walking, depression, and anger.

4. Does tiagabine cause depression?

Tiagabine may or may not cause depression. Its impact depends on the individual's medical condition and overall health.

5. Does tiagabine work for anxiety?

Tiagabine has shown efficacy in reducing anxiety symptoms in patients with generalized anxiety disorder (GAD). It may also improve sleep quality and overall functioning.

6. Is tiagabine safe?

Tiagabine, like other anticonvulsant medications, carries risks of affecting mental health. It's important to weigh the risks versus benefits under medical supervision.

7. Is gabitril and tiagabine the same?

Gabitril is the trade name for tiagabine, which is an anticonvulsant medication primarily used to treat epilepsy. It is also used off-label for anxiety disorders and panic disorder.

8. What is the mechanism of action of tiagabine?

Tiagabine works by blocking the uptake of GABA into presynaptic neurons, thereby increasing the availability of GABA for binding to receptors on postsynaptic cells. This action helps in regulating neuronal excitability.


Disclaimer: The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.

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